Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646195 | 0.89 | MAPT (0.33) | MAPTCACNA1BAPBA1 | |
| SCHEMBL8918344 | 0.84 | ALDH1A1 (0.43) | MAPTCASP1HSD17B10ALDH1A1 | |
| SCHEMBL28442159 | 0.75 | EGLN1 (0.47) | HSD17B10ALOX15SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL527804 | 0.71 | TSHR (0.47) | MAPTCACNA1BAPBA1CYP3A4TSHR | |
| SCHEMBL4680857 | 0.71 | CASP1 (0.45) | MAPTCACNA1BAPBA1CYP3A4CASP1 | |
| SCHEMBL9435890 | 0.71 | CYP3A4 (0.48) | MAPTCACNA1BAPBA1CYP3A4TSHR | |
| SCHEMBL8672977 | 0.70 | TSHR (0.46) | MAPTCACNA1BAPBA1CYP3A4TSHR | |
| SCHEMBL2659946 | 0.70 | CYP3A4 (0.44) | MAPTCACNA1BAPBA1CYP3A4TSHR | |
| Malonic Acid SCHEMBL31256740 | 0.70 | TSHR (0.46) | MAPTCACNA1BAPBA1CYP3A4TSHR | |
| SCHEMBL309469 | 0.70 | TSHR (0.46) | MAPTCACNA1BAPBA1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215739-B1 | SYNTHESIS OF BETA-LACTAM COMPOUNDS | CIBA-GEIGY AG (CH) | 1993-09-01 | — | — | EP | claimed |
| US-5215997-A | Synthesis of beta-lactam compounds | CIBA-GEIGY CORPORATION (US) | 1993-06-01 | — | — | US | claimed |
| EP-0278158-A2 | Renin inhibitors containing phenylalanyl-histidine replacements | MERCK & CO. INC. (US) | 1988-08-17 | — | — | EP | claimed |
| EP-0215739-A1 | Synthesis of beta-lactam compounds | CIBA-GEIGY AG (CH) | 1987-03-25 | — | — | EP | claimed |
| US-5463047-A | Intermediates for the manufacture of 4-acyloxy-3-hydroxyethylazetidinones | CIBA-GEIGY CORPORATION (US) | 1995-10-31 | — | — | US | disclosed |
| US-5386029-A | Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones | CIBA-GEIGY CORPORATION (US) | 1995-01-31 | — | — | US | disclosed |
| US-5274188-A | Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones | CIBA-GEIGY CORPORATION (US) | 1993-12-28 | — | — | US | disclosed |
| US-5064761-A | PROCESS FOR THE MANUFACTURE OF 4-ACYLAMINO-3-HYDROXYBUTYRIC ACID ESTERS | CIBA-GEIGY CORPORATION (US) | 1991-11-12 | — | — | US | disclosed |
| US-4927507-A | Novel process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones | CIBA-GEIGY CORPORATION (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0279781-A2 | Process for the preparation of 4-acetoxy-3-hydroxyethyl-acetidinone | CIBA-GEIGY AG (CH) | 1988-08-24 | — | — | EP | disclosed |