Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11567437 | 0.85 | DRD2 (0.49) | DRD2DRD3DRD4HTR7HTR1A | |
| SCHEMBL10752570 | 0.77 | HTR1A (0.54) | DRD2DRD3DRD4HTR7HTR1A | |
| SCHEMBL10749348 | 0.76 | KDM4E (0.47) | DRD2DRD3DRD4HTR4MAPK1 | |
| SCHEMBL9131776 | 0.73 | DRD2 (0.55) | DRD2DRD3DRD4ADORA2BHTR4 | |
| SCHEMBL11219802 | 0.71 | MAPT (0.33) | MAPK1HTR1AKDM4EADRA1DMAPT | |
| SCHEMBL10744900 | 0.71 | HTR7 (0.44) | DRD3HTR7HTR1AKDM4EMAPT | |
| SCHEMBL11567096 | 0.71 | ADORA2A (0.36) | DRD2DRD3DRD4 | |
| SCHEMBL11273685 | 0.71 | HTR2A (0.53) | DRD2DRD3DRD4ADORA2BHTR4 | |
| Mefeclorazine SCHEMBL2110367 | 0.71 | ADRA1D (0.73) | DRD2DRD3DRD4MAPK1HTR1A | |
| SCHEMBL29138034 | 0.71 | DRD2 (0.46) | DRD2DRD3DRD4ADORA2BHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579754-A1 | USE OF AMINES TO SENSITIZE MULTIDRUG-RESISTANT CELLS | THE UPJOHN COMPANY (US) | 1994-01-26 | — | — | EP | claimed |
| WO-1992018089-A2 | USE OF STEROIDAL AND NON-STEROIDAL AMINES TO SENSITIZE MULTIDRUG-RESISTANT CELLS | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | claimed |
| US-5436337-A | Anticarcinogenic agents | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| WO-1992018089-A2 | USE OF STEROIDAL AND NON-STEROIDAL AMINES TO SENSITIZE MULTIDRUG-RESISTANT CELLS | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |