Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.43 |
| ▸ | MAPT | P10636 | 12/20 | 0.43 |
| ▸ | MEN1 | O00255 | 11/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9156158 | 0.89 | MAPT (0.55) | KDM4EL3MBTL1HPGDCYP2C9DUSP3 | |
| SCHEMBL9622414 | 0.81 | MAPT (0.53) | KDM4EL3MBTL1HPGDKMT2AMAPT | |
| SCHEMBL9153484 | 0.79 | MAPT (0.47) | KDM4EL3MBTL1HPGDKMT2AMAPT | |
| SCHEMBL9622698 | 0.78 | ALDH1A1 (0.50) | KDM4EL3MBTL1HPGDKMT2AMAPT | |
| SCHEMBL11040384 | 0.77 | ALDH1A1 (0.45) | KDM4EHPGDKMT2AMAPTMEN1 | |
| SCHEMBL11040379 | 0.77 | ALDH1A1 (0.45) | KDM4EHPGDKMT2AMAPTMEN1 | |
| SCHEMBL48846 | 0.71 | KDM4E (0.62) | KDM4EL3MBTL1HPGDCYP2C9DUSP3 | |
| SCHEMBL30611012 | 0.71 | KDM4E (0.62) | KDM4EL3MBTL1HPGDCYP2C9DUSP3 | |
| Lithium Ion SCHEMBL18104080 | 0.71 | KDM4E (0.59) | KDM4EL3MBTL1HPGDCYP2C9DUSP3 | |
| SCHEMBL9622105 | 0.70 | MAPT (0.50) | L3MBTL1KMT2AMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0467155-B1 | Blue spectral sensitizers for non-tabular silver halide elements | DU PONT (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5102781-A | Used for radiographic elements designed for exposure to intensifying screens | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0467155-A1 | Blue spectral sensitizers for non-tabular silver halide elements | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |