Carbromal

Carbromal

SCHEMBL9170995

CCC(Br)(CC)C(=O)NC(N)=O.Nc1ccc([N+](=O)[O-])cn1.O=P(O)(O)O

nearest known ligand 0.42

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Carbromal. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 3/20 0.42
CYP1A2 P05177 2/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 8/20 0.38
NPC1 O15118 5/20 0.38
ALDH1A1 P00352 4/20 0.38
RAB9A P51151 4/20 0.38
LMNA P02545 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
ADRA2A P08913 2/20 0.36
ADRA2B P18089 2/20 0.36
ADRA2C P18825 2/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
KDM4E B2RXH2 2/20 0.35
HTT P42858 1/20 0.35
POLB P06746 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbromal SCHEMBL9724404 0.80 ALDH1A1 (0.49) GAAMAPTNPC1ALDH1A1SMN1; SMN2
Carbromal SCHEMBL9724461 0.79 ALDH1A1 (0.47) GAAMAPTNPC1ALDH1A1SMN1; SMN2
Phosphoric Acid SCHEMBL8529442 0.78 ADRA2A (0.50) CYP2C19CYP1A2GAAMAPTALDH1A1
Carbromal SCHEMBL620919 0.75 CRBN (0.33)
Carbromal SCHEMBL1537493 0.74 CRBN (0.32)
Phosphoric Acid SCHEMBL9079479 0.73 ADRA2A (0.47) CYP2C19CYP1A2GAAMAPTNPC1
Acetone SCHEMBL28243789 0.72 CYP1A2 (0.57) CYP2C19CYP1A2GAAMAPTNPC1
Carbromal SCHEMBL1499641 0.72 SLC34A1 (0.32)
Carbromal SCHEMBL995158 0.71 MMP1 (0.32)
Carbromal SCHEMBL11332793 0.71 CRBN (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5397508-A 2-amino-5-nitropyridinium salts usable in non-linear optics and in electroptics and a process for preparing the same FRANCE TELECOM ETABLISSEMENT AUTONOME DE DROIT PUBLIC (CENTRE NATIONAL D'ETUDES DES TELECOMMUNICATIONS) (FR) 1995-03-14 US disclosed