Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PTPRC | P08575 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPRF | P10586 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9353433 | 0.85 | L3MBTL1 (0.63) | MAPTLMNAPOLBNPSR1L3MBTL1 | |
| SCHEMBL8011558 | 0.79 | PKM (0.58) | POLBL3MBTL1ALDH1A1NPC1RAB9A | |
| SCHEMBL8727410 | 0.79 | MAPT (0.68) | MAPTLMNAPOLBL3MBTL1GAA | |
| SCHEMBL2170360 | 0.78 | CA12 (0.42) | MAPTLMNAPOLBNPSR1L3MBTL1 | |
| SCHEMBL11086552 | 0.78 | PARP10 (0.61) | ALDH1A1PARP10MAOB | |
| SCHEMBL10402918 | 0.78 | LMNA (0.53) | MAPTLMNAPOLBNPSR1L3MBTL1 | |
| SCHEMBL9553897 | 0.77 | MAPT (0.45) | MAPTLMNAPOLBNPSR1L3MBTL1 | |
| SCHEMBL13889134 | 0.76 | ALOX15 (0.57) | MAPTCES2CES1ALDH1A1 | |
| SCHEMBL11082868 | 0.75 | GABRA1 (0.46) | MAPTLMNAPOLBNPSR1L3MBTL1 | |
| SCHEMBL9175561 | 0.75 | MAPT (0.42) | MAPTLMNAPOLBNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383190-B1 | Ribonucleotide reductase inhibitors | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1995-06-14 | — | — | EP | disclosed |
| US-5198425-A | Bactericides | BIO-MEGA, INC. (CA) | 1993-03-30 | — | — | US | disclosed |
| US-5071835-A | Antitumor agents | BIO-MEGA INC. (CA) | 1991-12-10 | — | — | US | disclosed |
| EP-0383190-A2 | Ribonucleotide reductase inhibitors | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1990-08-22 | — | — | EP | disclosed |