Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (Z)-1,2-Diphenylethene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | CHAT | P28329 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL9176360 | 0.93 | TTR (0.48) | RELACHATMAOBTRPA1ALOX5 | |
| Diethylamine SCHEMBL8573851 | 0.88 | CYP11B2 (0.47) | RELAALOX5LMNACYP19A1GRM5 | |
| Cinnamaldehyde SCHEMBL8420413 | 0.85 | ALDH1A1 (0.72) | RELAMAOBTRPA1ALOX5ALDH1A1 | |
| SCHEMBL13973036 | 0.83 | HDAC3 (0.50) | RELAMAOBTRPA1ALDH1A1LMNA | |
| Diethylamine SCHEMBL10429608 | 0.83 | RELA (0.43) | RELACHATMAOBTRPA1NFE2L2 | |
| Benzaldehyde SCHEMBL316996 | 0.83 | ALDH1A1 (0.67) | MAOBTRPA1ALOX5ALDH1A1LMNA | |
| SCHEMBL2189374 | 0.82 | RAB9A (0.53) | RELAMAOBALDH1A1RAB9AKDM4E | |
| SCHEMBL2189373 | 0.82 | RAB9A (0.53) | RELAMAOBALDH1A1RAB9AKDM4E | |
| Cinnamic Acid SCHEMBL28879066 | 0.82 | HDAC3 (0.70) | ALDH1A1LMNAKMT2ACYP1A2PTGS2 | |
| Styrene SCHEMBL523206 | 0.81 | ALDH1A1 (0.64) | RELAALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347854-B1 | Photoreceptor for electrophotography | KAO CORP (JP) | 1995-06-07 | — | — | EP | disclosed |
| US-5032479-A | Charge transport compound | KAO CORPORATION (JP) | 1991-07-16 | — | — | US | disclosed |
| EP-0347854-A2 | Photoreceptor for electrophotography | KAO CORPORATION (JP) | 1989-12-27 | — | — | EP | disclosed |