SCHEMBL918583

SCHEMBL918583

COc1ccc(C(OC[C@@H]2O[C@H](n3ccc(=O)[nH]c3=O)C(O)C2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.62
P2RY14 Q15391 5/20 0.59
P2RY2 P41231 11/20 0.54
P2RY6 Q15077 10/20 0.54
SLC28A1 O00337 1/20 0.53
SLC28A2 O43868 1/20 0.53
SLC29A1 Q99808 1/20 0.53
SLC28A3 Q9HAS3 1/20 0.53
P2RY4 P51582 5/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL918582 1.00 TYMP (0.62) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL1317089 1.00 TYMP (0.62) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL12513082 1.00 TYMP (0.62) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL26502752 1.00 TYMP (0.62) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL12434636 1.00 TYMP (0.62) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL26502736 0.93 TYMP (0.56) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL4085510 0.92 SLC28A1 (0.62) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL8332109 0.92 SLC28A1 (0.62) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL22983983 0.92 TYMP (0.53) TYMPP2RY14P2RY2P2RY6SLC28A1
SCHEMBL8209464 0.92 P2RY6 (0.54) TYMPP2RY14P2RY2P2RY6SLC28A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025038971-A1 OLIGONUCLEOTIDES CONTAINING A LIGAND AT A NUCLEOBASE, 2' POSITION, OR 3' POSITION ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO disclosed
US-10457945-B2 UNA oligomers for therapeutics with prolonged stability ARCTURUS THERAPEUTICS, INC. (US) 2019-10-29 US disclosed
US-20180237780-A1 UNA OLIGOMERS FOR THERAPEUTICS WITH PROLONGED STABILITY MARINA BIOTECH, INC. 2018-08-23 US disclosed
US-9944929-B2 UNA single stranded oligomers for therapeutics ARCTURUS THERAPEUTICS, INC. (US) 2018-04-17 US disclosed
EP-1995253-B1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID NIPPON SHINYAKU CO LTD (JP) 2016-12-21 EP disclosed
EP-3045535-A1 HYDROXYMETHYL SUBSTITUTED RNA OLIGONUCLEOTIDES AND RNA COMPLEXES Arcturus Therapeutics, Inc. (US) 2016-07-20 EP disclosed
US-20160168567-A1 UNA SINGLE STRANDED OLIGOMERS FOR THERAPEUTICS MARINA BIOTECH, INC. 2016-06-16 US disclosed
CN-101679978-B Hydroxymethyl substituted RNA oligonucleotides and RNA complexes ARCTURUS THERAPEUTICS, INC. (US) 2016-05-04 CN disclosed
EP-2162538-B1 OLIGOMERS FOR THERAPEUTICS ARCTURUS THERAPEUTICS INC (US) 2016-04-20 EP disclosed
US-9303260-B2 UNA duplex oligomers for therapeutics ARCTURUS THERAPEUTICS, INC. (US) 2016-04-05 US disclosed
EP-1644479-A4 FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENE DELIVERY GRINSTAFF MARK W (US) 2008-04-23 EP disclosed
EP-1639121-A4 SYNTHESIS OF BETA -L-2-DEOXY NUCLEOSIDES IDENIX CAYMAN LTD (KY) 2008-04-16 EP disclosed
US-20070282097-A1 Phosphoramidite Compound And Method For Producing Oligo-Rna NIPPON SHINYAKU CO., LTD. (JP) 2007-12-06 US disclosed
EP-1795536-A1 PHOSPHORAMIDITE COMPOUND AND METHOD FOR PRODUCING OLIGO-RNA Nippon Shinyaku Co., Ltd. (JP) 2007-06-13 EP disclosed
US-20060241071-A1 Functional synthetic molecules and macromolecules for gene delivery FIFTH BASE LLC 2006-10-26 US disclosed
EP-1644479-A2 FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENE DELIVERY Grinstaff, Mark, W. (US) 2006-04-12 EP disclosed
EP-1639121-A2 SYNTHESIS OF BETA -L-2-DEOXY NUCLEOSIDES Idenix (Cayman) Limited (KY) 2006-03-29 EP disclosed
US-20050059632-A1 Synthesis of beta-L-2'-deoxy nucleosides NOVARTIS AG (CH) 2005-03-17 US disclosed
WO-2005007810-A2 FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENE DELIVERY GRINSTAFF MARK W (US) 2005-01-27 WO disclosed
WO-2005003374-A2 SYNTHESIS OF β-L-2-DEOXY NUCLEOSIDES IDENIX (CAYMAN) LIMITED (KY) 2005-01-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060241071-A1 Functional synthetic molecules and macromolecules for gene delivery ANXA6, STING1, POLRMT TYMP 2413/4885P2RY14 3315/4885P2RY2 3058/4885
US-10457945-B2 UNA oligomers for therapeutics with prolonged stability NOP2, NONO, NSUN3 TYMP 482/4885P2RY14 3103/4885P2RY2 1939/4885
US-20070282097-A1 Phosphoramidite Compound And Method For Producing Oligo-Rna NSUN2, NSUN3, XRN2 TYMP 485/4885P2RY14 1889/4885P2RY2 1095/4885
US-20180237780-A1 UNA OLIGOMERS FOR THERAPEUTICS WITH PROLONGED STABILITY NOP2, NONO, NSUN3 TYMP 482/4885P2RY14 3103/4885P2RY2 1939/4885
US-20050059632-A1 Synthesis of beta-L-2'-deoxy nucleosides DUT, DERA, RNASEL TYMP 25/4885P2RY14 1903/4885P2RY2 1816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.