Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476373 | 0.86 | ALOX5 (0.43) | ALOX5GRM5NPC1RAB9ACYP2A6 | |
| SCHEMBL9299977 | 0.83 | ALOX5 (0.39) | ALOX5PTGS1PTGS2GRM5CYP2A6 | |
| SCHEMBL9221256 | 0.78 | HSD11B1 (0.46) | ALOX5PTGS1PTGS2NPC1RAB9A | |
| SCHEMBL9190852 | 0.78 | FFAR1 (0.58) | ALOX5PTGS1PTGS2GRM5ACACB | |
| SCHEMBL9299727 | 0.76 | FFAR1 (0.38) | ALOX5PTGS1PTGS2GRM5FFAR1 | |
| SCHEMBL9195674 | 0.73 | ALOX5 (0.47) | ALOX5PTGS1PTGS2ACACBRAB9A | |
| SCHEMBL9192424 | 0.73 | ALOX5 (0.48) | ALOX5FFAR1 | |
| SCHEMBL9192422 | 0.72 | FFAR1 (0.58) | ALOX5PTGS1PTGS2GRM5ACACB | |
| SCHEMBL9192563 | 0.71 | PTGES (0.56) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9299297 | 0.70 | ALOX5 (0.37) | ALOX5GRM5IKBKBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468281-B1 | Substituted phenylacetylenes, pharmaceuticals containing them and methods for the preparation of these compounds and pharmaceuticals | GRUENENTHAL GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5202349-A | Lipoxygenase inhibitors, antiasthatics | GRUENENTHAL GMBH (DE) | 1993-04-13 | — | — | US | disclosed |
| EP-0468281-A1 | Substituted phenylacetylenes, pharmaceuticals containing them and methods for the preparation of these compounds and pharmaceuticals | Grünenthal GmbH (DE) | 1992-01-29 | — | — | EP | disclosed |