Sugi Predict

Sugi Predict / Compounds / SCHEMBL919534

SCHEMBL919534

SCHEMBL919534

N#CCCSN1C(=O)c2ccccc2C1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD3 P35462 3/20 0.45
▸ CA9 Q16790 3/20 0.42
▸ CA2 P00918 1/20 0.42
▸ ALDH1A1 P00352 4/20 0.39
▸ MAPT P10636 2/20 0.39
▸ CA12 O43570 2/20 0.39
▸ PKM P14618 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ ALOX12 P18054 1/20 0.39
▸ MC4R P32245 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ CASP3 P42574 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ SENP8 Q96LD8 1/20 0.39
▸ SENP7 Q9BQF6 1/20 0.39
▸ SENP6 Q9GZR1 1/20 0.39
▸ CYP2C19 P33261 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29845994 1.00 DRD3 (0.45) DRD3CA9CA2ALDH1A1MAPT
SCHEMBL11803233 0.79 CYP1A2 (0.43) ALDH1A1MAPTPKMHPGDALOX15
SCHEMBL11604125 0.77 CASP3 (0.41) CA9ALDH1A1MAPTCA12PKM
SCHEMBL10335606 0.77 DRD3 (0.44) DRD3CA9ALDH1A1MAPTCA12
SCHEMBL29210117 0.76 CASP3 (0.50) CA9ALDH1A1MAPTCA12PKM
SCHEMBL10351412 0.74 SOAT1 (0.45) DRD3CA9ALDH1A1CA12CYP2C19
SCHEMBL29459546 0.73 DRD3 (0.55) DRD3CA9CA2ALDH1A1MAPT
SCHEMBL6993290 0.73 DRD3 (0.55) DRD3CA9CA2ALDH1A1MAPT
SCHEMBL5847525 0.73 SOAT1 (0.46) DRD3CA9ALDH1A1CA12
SCHEMBL10351913 0.72 ALDH1A1 (0.43) DRD3CA9ALDH1A1MAPTCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12492220-B2 Method for the preparation of oligonucleotides THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2025-12-09 — — US claimed
CN-113631564-B Method for producing oligonucleotide having phosphorothioate site 味之素株式会社 2025-02-25 — — CN claimed
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV (CA) 2023-06-22 — — US claimed
EP-3950698-A1 METHOD FOR PRODUCING OLIGONUCLEOTIDE HAVING PHOSPHOROTHIOATE SITE AJINOMOTO CO., INC. (JP) 2022-02-09 — — EP claimed
US-20220010348-A1 METHOD FOR PRODUCING OLIGONUCLEOTIDE HAVING PHOSPHOROTHIOATED SITE AJINOMOTO CO., INC. (JP) 2022-01-13 — — US claimed
US-7871746-B2 Thiophthalimides containing photoconductors XEROX CORPORATION (US) 2011-01-18 — — US claimed
US-20090274971-A1 THIOPHTHALIMIDES CONTAINING PHOTOCONDUCTORS XEROX CORPORATION (US) 2009-11-05 — — US claimed
EP-0723973-B1 Nucleoside phosphorothioate derivatives, synthesis and use thereof KING S COLLEGE LONDON (GB) 1998-10-21 — — EP claimed
US-5708161-A Nucleoside phosphorothioate derivatives, synthesis and use thereof KING'S COLLEGE LONDON (GB) 1998-01-13 — — US claimed
EP-0723973-A1 Nucleoside phosphorothioate derivatives, synthesis and use thereof KING'S COLLEGE LONDON (GB) 1996-07-31 — — EP claimed
US-12492220-B2 Method for the preparation of oligonucleotides THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2025-12-09 — — US disclosed
CN-113631564-B Method for producing oligonucleotide having phosphorothioate site 味之素株式会社 2025-02-25 — — CN disclosed
US-20240084295-A1 Novel Synthesis of Phosphorodithioate Oligonucleotides HOFFMANN LA ROCHE (US) 2024-03-14 — — US disclosed
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV (CA) 2023-06-22 — — US disclosed
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV (CA) 2023-06-22 — — US disclosed
WO-1999009041-A2 SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES AVECIA LIMITED (GB) 1999-02-25 — — WO disclosed
EP-0723973-B1 Nucleoside phosphorothioate derivatives, synthesis and use thereof KING S COLLEGE LONDON (GB) 1998-10-21 — — EP disclosed
US-5708161-A Nucleoside phosphorothioate derivatives, synthesis and use thereof KING'S COLLEGE LONDON (GB) 1998-01-13 — — US disclosed
WO-1997029116-A1 SULPHUR CONTAINING DINUCLEOTIDE PHOSPHORAMIDITES CRUACHEM LIMITED (GB) 1997-08-14 — — WO disclosed
EP-0723973-A1 Nucleoside phosphorothioate derivatives, synthesis and use thereof KING'S COLLEGE LONDON (GB) 1996-07-31 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220010348-A1 METHOD FOR PRODUCING OLIGONUCLEOTIDE HAVING PHOSPHOROTHIOATED SITE RNGTT, NUDT1, ADAR DRD3 2977/4885CA9 2121/4885CA2 2571/4885
US-12492220-B2 Method for the preparation of oligonucleotides POLN, POLRMT, POLI DRD3 4714/4885CA9 3522/4885CA2 4013/4885
US-20240084295-A1 Novel Synthesis of Phosphorodithioate Oligonucleotides TYMS, TYMP, RNGTT DRD3 4446/4885CA9 4005/4885CA2 4557/4885
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES POLN, POLRMT, POLI DRD3 4714/4885CA9 3522/4885CA2 4013/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.