Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1516246 | 0.82 | MAPK1 (0.58) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL137832 | 0.80 | MAPK1 (0.56) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL1699941 | 0.78 | RECQL (0.58) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL260911 | 0.78 | ALDH1A1 (0.56) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL7868384 | 0.78 | MAPK1 (0.54) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL2188285 | 0.78 | MAPT (0.54) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL15791249 | 0.78 | MAPK1 (0.54) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL7149069 | 0.78 | MAPK1 (0.54) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL113872 | 0.78 | MAPK1 (0.54) | MAPK1MAPTTDP1MEN1CYP3A4 | |
| SCHEMBL452973 | 0.77 | HSD11B1 (0.77) | MAPK1MAPTMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4958018-A | REACTING A 3-HALOMETHYL-3-CEPHEM WITH A LEAD REDUCING AGENT | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1990-09-18 | — | — | US | claimed |
| EP-0341694-B1 | Method for production of 3-exomethylenecepham derivatives | OTSUKA KAGAKU KK (JP) | 1995-09-06 | — | — | EP | disclosed |
| US-4958018-A | REACTING A 3-HALOMETHYL-3-CEPHEM WITH A LEAD REDUCING AGENT | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1990-09-18 | — | — | US | disclosed |
| US-4956358-A | ANTIBIOTICS, BACTERICIDES, CEPHALOSPORINS AND ISOCEPHALOSPORINS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| US-4906659-A | Antibiotic tan-749, its derivatives, production and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-03-06 | — | — | US | disclosed |
| US-4897489-A | 2-/5-OXO-2-TETRAHYDROFURANY4-3-OXOISOXOL-IDINE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| US-4891427-A | BACTERICIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-02 | — | — | US | disclosed |
| EP-0341694-A2 | Method for production of 3-exomethylenecepham derivatives | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1989-11-15 | — | — | EP | disclosed |
| US-4876251-A | ANTIBIOTICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-10-24 | — | — | US | disclosed |
| US-4851422-A | Antibiotic 2-(3-oxo-2-isoxazolidinyl)-5-oxo-2-tetrahydrofuran-carboxylates | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0271829-A2 | Delta-hydroxy-beta-lysine derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1988-06-22 | — | — | EP | disclosed |
| EP-0249909-A1 | Tricyclic penam compounds, their production and their use | Takeda Chemical Industries, Ltd. (JP) | 1987-12-23 | — | — | EP | disclosed |
| EP-0250096-A1 | Isoxazolone derivatives and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1987-12-23 | — | — | EP | disclosed |
| EP-0219923-A1 | Antibiotic derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-04-29 | — | — | EP | disclosed |
| EP-0191989-A1 | Antibiotic isoxazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-08-27 | — | — | EP | disclosed |