SCHEMBL920288

SCHEMBL920288

COCc1ccc(C(=O)NCc2ccc(Oc3ccc(C#N)cc3)cc2)c(N)n1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 6/20 0.46
AKR1B1 P15121 1/20 0.44
PPARA Q07869 1/20 0.42
EPHX2 P34913 1/20 0.42
ADORA2A P29274 1/20 0.41
MAPK8 P45983 1/20 0.41
MAPK9 P45984 1/20 0.41
KLKB1 P03952 1/20 0.41
KLK1 P06870 1/20 0.41
PDPK1 O15530 1/20 0.40
CACNA1G O43497 1/20 0.40
CACNA1B Q00975 1/20 0.40
GSK3B P49841 2/20 0.39
KMT2A Q03164 1/20 0.39
EGLN1 Q9GZT9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920738 0.91 SCN9A (0.42) SCN9AAKR1B1ADORA2AMAPK8MAPK9
SCHEMBL922841 0.89 EGLN1 (0.49) ADORA2AKMT2AEGLN1
SCHEMBL922173 0.88 POLB (0.48) EPHX2KLKB1KLK1EGLN1
SCHEMBL920018 0.88 TP53 (0.41) PPARAKMT2AEGLN1
SCHEMBL922079 0.88 MAPK14 (0.50) KMT2AEGLN1
SCHEMBL919997 0.88 MAPK14 (0.50) PPARAEPHX2MAPK8KLKB1KLK1
SCHEMBL920880 0.87 EGLN1 (0.41) KMT2AEGLN1
SCHEMBL920779 0.87 LIPG (0.51) SCN9APPARA
SCHEMBL921652 0.87 AKR1B1 (0.41) AKR1B1KMT2AEGLN1
SCHEMBL920636 0.87 CYP3A4 (0.48) ADORA2AKMT2AEGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 SCN9A 1203/4885AKR1B1 1454/4885PPARA 494/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.