Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.46 |
| ▸ | MMP13 | P45452 | 11/20 | 0.44 |
| ▸ | MMP9 | P14780 | 9/20 | 0.44 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.44 |
| ▸ | MMP7 | P09237 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 8/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15274643 | 0.84 | ADAM17 (0.58) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL919681 | 0.82 | MTNR1A (0.43) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL922728 | 0.82 | GAA (0.36) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL921231 | 0.80 | KCNA3 (0.35) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL920286 | 0.80 | ALDH1A1 (0.38) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL9155604 | 0.79 | KCNH2 (0.40) | — | |
| SCHEMBL921844 | 0.79 | KCNA3 (0.39) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL9338770 | 0.78 | KCNH2 (0.55) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL6265267 | 0.78 | KCNH2 (0.55) | ADAM17MMP13MMP9MMP2MMP8 | |
| SCHEMBL29072947 | 0.78 | ADAM17 (0.49) | ADAM17MMP13MMP9MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516426-B1 | BIS(DIFLUORMETHYL)PYRAZOLES USED AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2015-09-16 | — | — | EP | claimed |
| US-20140057945-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-27 | — | — | US | claimed |
| US-8524743-B2 | Bis(difluoromethyl)pyrazoles as fungicides | BAYER CROPSCIENCE AG (DE) | 2013-09-03 | — | — | US | claimed |
| US-20110224257-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER CROPSCIENCE AG (DE) | 2011-09-15 | — | — | US | claimed |
| US-9751871-B2 | Bis(difluoromethyl)pyrazoles as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-09-05 | — | — | US | disclosed |
| US-20160214970-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-07-28 | — | — | US | disclosed |
| US-9247748-B2 | Bis(difluoromethyl)pyrazoles as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9167821-B2 | Bis(difluoromethyl)pyrazoles as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| US-20150065541-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-05 | — | — | US | disclosed |
| US-20140057945-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-27 | — | — | US | disclosed |
| US-8524743-B2 | Bis(difluoromethyl)pyrazoles as fungicides | BAYER CROPSCIENCE AG (DE) | 2013-09-03 | — | — | US | disclosed |
| US-20110224257-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER CROPSCIENCE AG (DE) | 2011-09-15 | — | — | US | disclosed |
| US-7595317-B2 | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-29 | — | — | US | disclosed |
| US-7294624-B2 | Osteoporosis; antiarthritic agents | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-11-13 | — | — | US | disclosed |
| US-20070167451-A1 | BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-alpha CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES | DUAN JINGWU | 2007-07-19 | — | — | US | disclosed |
| WO-2003053941-A2 | BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-ALPHA CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-03 | — | — | WO | disclosed |
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1144368-A2 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |
| WO-2000044709-A2 | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167451-A1 | BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-alpha CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES | TNF, MMP9, MMP3 | ADAM17 27/4885MMP13 8/4885MMP9 2/4885 |
| US-20150065541-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | CYP1A1, CYP4X1, CYP2F1 | ADAM17 3918/4885MMP13 4809/4885MMP9 4329/4885 |
| US-20160214970-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | CYP1A1, CYP4X1, CYP2F1 | ADAM17 3918/4885MMP13 4809/4885MMP9 4329/4885 |
| US-20110224257-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | CYP1A1, CYP4X1, CYP2F1 | ADAM17 3918/4885MMP13 4809/4885MMP9 4329/4885 |
| US-20140057945-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | CYP1A1, CYP4X1, CYP2F1 | ADAM17 3918/4885MMP13 4809/4885MMP9 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.