Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216452 | 0.94 | MEN1 (0.36) | MEN1KMT2AMCHR1ADRA1AHTR1A | |
| SCHEMBL9213796 | 0.92 | MTNR1A (0.41) | MTNR1AMTNR1BMEN1KMT2AKCNH2 | |
| SCHEMBL9206494 | 0.92 | MTNR1A (0.41) | MTNR1AMTNR1BMEN1KMT2AMCHR1 | |
| SCHEMBL9216877 | 0.90 | ACHE (0.35) | MEN1KMT2AMCHR1ADRA1AHTR1A | |
| SCHEMBL9206684 | 0.88 | HTR1A (0.41) | MTNR1AMEN1KMT2AHTR1A | |
| SCHEMBL9214365 | 0.87 | HCN4 (0.40) | MTNR1AMTNR1BKCNH2HTR1ASLC6A4 | |
| SCHEMBL9205646 | 0.86 | MEN1 (0.40) | MTNR1AMTNR1BMEN1KMT2AMCHR1 | |
| SCHEMBL9205217 | 0.86 | HCN4 (0.40) | MEN1KMT2AKCNH2HTR1ASLC6A4 | |
| SCHEMBL9215793 | 0.86 | HTR1A (0.39) | MTNR1AMEN1KMT2AHTR1A | |
| SCHEMBL9740732 | 0.85 | MEN1 (0.46) | MEN1KMT2AMCHR1HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |