Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 5/20 | 0.44 |
| ▸ | TUBB | P07437 | 5/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220993 | 0.91 | MTNR1A (0.44) | HSD17B10USP2MTNR1BMTNR1AKDM4E | |
| SCHEMBL12209489 | 0.82 | AKR1C2 (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13698343 | 0.80 | HTR6 (0.52) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9451736 | 0.80 | PTGES2 (0.34) | HSD17B10MAPK1MTNR1BMTNR1AKDM4E | |
| SCHEMBL12510343 | 0.79 | ALDH1A1 (0.45) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1193617 | 0.79 | ALDH1A1 (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9581350 | 0.75 | PTGES (0.40) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9581649 | 0.74 | ALOX5 (0.38) | HSD17B10USP2MAPK1KDM4EALDH1A1 | |
| SCHEMBL12510346 | 0.74 | KDM4E (0.33) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9150374 | 0.74 | ALDH1A1 (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419049-B1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC (CA) | 1995-04-12 | — | — | EP | disclosed |
| US-5380850-A | Quinoline hydrazine intermediates | MERCK FROSST CANADA, INC. (CA) | 1995-01-10 | — | — | US | disclosed |
| WO-1994013293-A2 | (QUINOLIN-2-YLMETHOXY)INDOLES AS INHIBITORS OF THE BIOSYNTHESIS OF LEUKOTRIENES | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |
| US-5272145-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-12-21 | — | — | US | disclosed |
| US-5204344-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| US-5202321-A | Antihistamine, antiallergens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1993-04-13 | — | — | US | disclosed |
| EP-0518426-A1 | Thiopyrano (2,3,4-c,d) indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-12-16 | — | — | EP | disclosed |
| EP-0419049-A1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC. (CA) | 1991-03-27 | — | — | EP | disclosed |