Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.52 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR5A | P47898 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12510343 | 0.84 | ALDH1A1 (0.45) | HTR6HTR1DHTR1AHTR2AHTR2C | |
| SCHEMBL12209489 | 0.83 | AKR1C2 (0.55) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1193617 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL9217686 | 0.80 | TUBB4A (0.44) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL12510345 | 0.80 | GAA (0.39) | HTR6HTR1DHTR2AHTR2CHTR7 | |
| SCHEMBL9150374 | 0.76 | ALDH1A1 (0.68) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL22722590 | 0.76 | HTR6 (0.59) | HTR6HTR1DHTR1AHTR2AHTR2C | |
| SCHEMBL12510346 | 0.74 | KDM4E (0.33) | HTR6HTR1DHTR1AHTR2AHTR2C | |
| SCHEMBL15902404 | 0.71 | AHR (0.58) | HTR6HTR1DHTR1AHTR2AHTR2C | |
| SCHEMBL9200463 | 0.71 | HTR6 (0.75) | HTR6HTR1DHTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221574-A1 | 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221574-A1 | 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors | ALOX5, ALOX15B, ALOX15 | HTR6 2058/4885HTR1D 1720/4885HTR1A 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.