Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.43 |
| ▸ | HCK | P08631 | 6/20 | 0.43 |
| ▸ | SRC | P12931 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.43 |
| ▸ | PRKDC | P78527 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9221267 | 0.86 | SMN1; SMN2 (0.40) | PIK3CDHCKSRCKDRABL1 | |
| SCHEMBL9216188 | 0.86 | RAB9A (0.36) | PIK3CDHCKSRCKDRABL1 | |
| SCHEMBL9220988 | 0.84 | MAPT (0.45) | PIK3CDHCKSRCKDRABL1 | |
| SCHEMBL9219923 | 0.82 | DGAT1 (0.39) | HCKSRCKDRALDH1A1SMN1; SMN2 | |
| SCHEMBL9219419 | 0.82 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL9216083 | 0.81 | ALDH1A1 (0.36) | PIK3CDHCKSRCKDRABL1 | |
| SCHEMBL9215756 | 0.79 | SRC (0.45) | HCKSRCKDRABL1EGFR | |
| SCHEMBL9220600 | 0.79 | RAB9A (0.38) | PIK3CDHCKSRCKDRABL1 | |
| SCHEMBL9215740 | 0.79 | KMO (0.41) | PIK3CDSRCABL1PIK3CAPIK3CB | |
| SCHEMBL9220312 | 0.79 | RAB9A (0.39) | KDRALDH1A1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |