Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL14735910 | 0.84 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7544755 | 0.80 | — | — | |
| Tromethamine SCHEMBL17484 | 0.77 | MEN1 (1.00) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3696191 | 0.77 | — | — | |
| Tromethamine SCHEMBL975 | 0.77 | — | — | |
| Tromethamine SCHEMBL20187683 | 0.74 | MEN1 (0.77) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9298764 | 0.73 | — | — | |
| Tromethamine SCHEMBL445853 | 0.73 | MEN1 (0.91) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL2263148 | 0.73 | MEN1 (0.91) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL2035496 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644869-A4 | ION PAIRS OF HYPERICIN COMPOUNDS HAVING ANTIVIRAL ACTIVITY. | — | 1995-04-12 | — | — | EP | disclosed |
| EP-0644869-A1 | ION PAIRS OF HYPERICIN COMPOUNDS HAVING ANTIVIRAL ACTIVITY | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 1995-03-29 | — | — | EP | disclosed |