Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL975 | 0.91 | — | — | |
| Tromethamine SCHEMBL17484 | 0.91 | MEN1 (1.00) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL3696191 | 0.91 | — | — | |
| Tromethamine SCHEMBL20187683 | 0.88 | MEN1 (0.77) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL6427079 | 0.87 | — | — | |
| Tromethamine SCHEMBL7126002 | 0.87 | — | — | |
| Tromethamine SCHEMBL7091147 | 0.87 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.87 | — | — | |
| Tromethamine SCHEMBL2263148 | 0.87 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL4388579 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030116-A1 | CONSTRUCTS AND METHODS FOR INCREASING YIELD OF FATTY ALCOHOLS IN CYANOBACTERIA | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 2013-03-07 | — | — | WO | disclosed |
| US-20130059350-A1 | CONSTRUCTS AND METHODS FOR INCREASING YIELD OF FATTY ALCOHOLS IN CYANOBACTERIA | SHELL OIL COMPANY (US) | 2013-03-07 | — | — | US | disclosed |