Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29381205 | 1.00 | HIF1A (0.39) | HIF1AMEN1CYP3A4HPGDALOX15 | |
| SCHEMBL3657647 | 0.88 | CYP3A4 (0.42) | HIF1AMEN1CYP3A4HPGDALOX15 | |
| SCHEMBL30360703 | 0.88 | CYP3A4 (0.42) | HIF1AMEN1CYP3A4HPGDALOX15 | |
| SCHEMBL17410220 | 0.85 | PYCR1 (0.41) | HIF1AMEN1CYP3A4HPGDALOX15 | |
| SCHEMBL2560634 | 0.83 | NOS3 (0.44) | HIF1AMEN1CYP3A4HPGDALOX15 | |
| SCHEMBL81974 | 0.80 | IDO1 (0.42) | HIF1AMEN1CYP3A4HPGDALOX15 | |
| SCHEMBL500015 | 0.79 | CYP3A4 (0.45) | HIF1AMEN1CYP3A4HPGDALOX15 | |
| SCHEMBL6682244 | 0.79 | NOS3 (0.40) | MEN1CYP3A4ALOX15KMT2ASMN1; SMN2 | |
| SCHEMBL28815989 | 0.79 | NOS3 (0.37) | HIF1AMEN1CYP3A4HPGDALOX15 | |
| SCHEMBL12713148 | 0.79 | ACLY (0.36) | HIF1AMEN1CYP3A4HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459950-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2025-11-04 | — | — | US | disclosed |
| US-12440506-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2025-10-14 | — | — | US | disclosed |
| CN-115583951-B | Method for synthesizing intermediate E8 for preparing BRD4 protein inhibitor | 博诺康源(北京)药业科技有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-111971288-B | Selective inhibitors of protein arginine methyltransferase 5 (PRMT 5) | 普莱鲁德疗法有限公司 | 2023-12-01 | — | — | CN | disclosed |
| EP-3765461-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-115583951-A | Method for synthesizing intermediate E8 for preparing BRD4 protein inhibitor | 博诺康源(北京)药业科技有限公司 | 2023-01-10 | — | — | CN | disclosed |
| US-20220177481-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED | 2022-06-09 | — | — | US | disclosed |
| US-20220152073-A1 | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2022-05-19 | — | — | US | disclosed |
| US-11254683-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED (US) | 2022-02-22 | — | — | US | disclosed |
| EP-3946352-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | Prelude Therapeutics, Incorporated (US) | 2022-02-09 | — | — | EP | disclosed |
| US-20200361945-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2020-11-19 | — | — | US | disclosed |
| WO-2020206299-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2020-10-08 | — | — | WO | disclosed |
| WO-2020206299-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2020-10-08 | — | — | WO | disclosed |
| US-20200291037-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2020-09-17 | — | — | US | disclosed |
| US-10711007-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED (US) | 2020-07-14 | — | — | US | disclosed |
| US-20190284193-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2019-09-19 | — | — | US | disclosed |
| WO-2019178368-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-09-19 | — | — | WO | disclosed |
| US-20110009399-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-01-13 | — | — | US | disclosed |
| EP-2231677-A2 | TRISUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | Novartis AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009074674-A2 | TRISUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009399-A1 | ORGANIC COMPOUNDS | REN, ACE, AGTR1 | HIF1A 2763/4885MEN1 1714/4885CYP3A4 112/4885 |
| US-12459950-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2311/4885MEN1 2150/4885CYP3A4 2766/4885 |
| US-10711007-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2311/4885MEN1 2150/4885CYP3A4 2766/4885 |
| US-11254683-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2311/4885MEN1 2150/4885CYP3A4 2766/4885 |
| US-20200361945-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2311/4885MEN1 2150/4885CYP3A4 2766/4885 |
| US-20220152073-A1 | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2516/4885MEN1 2374/4885CYP3A4 2775/4885 |
| US-12440506-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2516/4885MEN1 2374/4885CYP3A4 2775/4885 |
| US-20190284193-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2311/4885MEN1 2150/4885CYP3A4 2766/4885 |
| US-20220177481-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2311/4885MEN1 2150/4885CYP3A4 2766/4885 |
| US-20200291037-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | HIF1A 2311/4885MEN1 2150/4885CYP3A4 2766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.