Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258660 | 0.87 | F2 (0.44) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL9257912 | 0.85 | NR1H4 (0.61) | KMT2AMEN1NR1H4L3MBTL1HDAC8 | |
| SCHEMBL562313 | 0.81 | ALDH1A1 (0.62) | KMT2AMEN1NR1H4L3MBTL1HDAC8 | |
| SCHEMBL9248638 | 0.80 | RXRA (0.53) | HDAC8ALDH1A1TDP1 | |
| SCHEMBL159777 | 0.77 | NR1H4 (0.47) | KMT2AMEN1NR1H4L3MBTL1LMNA | |
| SCHEMBL9254014 | 0.76 | NQO2 (0.55) | MAPTALDH1A1KDM4EPKMSMN1; SMN2 | |
| SCHEMBL24073125 | 0.75 | NR1H4 (0.64) | KMT2AMEN1NR1H4L3MBTL1MAPT | |
| SCHEMBL9250170 | 0.74 | NQO2 (0.61) | ALDH1A1TDP1 | |
| SCHEMBL9254531 | 0.74 | TMPRSS15 (0.43) | MAPTGAASMN1; SMN2 | |
| SCHEMBL14018791 | 0.74 | HSD17B10 (0.47) | KMT2AMEN1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463071-A | Tetrazole derivatives; useful for inhibiting undesirable cell aggregation | DR. KARL THOMAE GMBH (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0525629-A2 | 5-membered heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |