Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | MMP13 | P45452 | 7/20 | 0.56 |
| ▸ | MMP2 | P08253 | 5/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870168 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL2391276 | 0.81 | KDM4E (0.67) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL85706 | 0.80 | RAB9A (1.00) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL30994860 | 0.80 | RAB9A (1.00) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL30899145 | 0.80 | KMT2A (0.59) | KDM4ERAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL7079692 | 0.79 | MMP13 (0.71) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9263164 | 0.79 | KDM4E (0.80) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL75327 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL5680973 | 0.77 | KDM4E (0.76) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL30181833 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |