Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325535 | 0.95 | FPR2 (0.47) | TRPC6FPR2MAPTMEN1KMT2A | |
| SCHEMBL12989431 | 0.88 | ALDH1A1 (0.42) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL1752782 | 0.85 | ALDH1A1 (0.50) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9179120 | 0.84 | MAPT (0.43) | FPR2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9263478 | 0.83 | XDH (0.59) | TRPC6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9324686 | 0.82 | FPR2 (0.46) | TRPC6FPR2MAPTMEN1KMT2A | |
| SCHEMBL9325828 | 0.79 | MAPT (0.47) | FPR2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9325859 | 0.78 | FPR2 (0.47) | FPR2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL12989185 | 0.78 | QPCT (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9271648 | 0.78 | SMN1; SMN2 (0.43) | TRPC6MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449676-A | Bronchodilator agents | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1995-09-12 | — | — | US | disclosed |
| EP-0581805-A1 | NOVEL PYRIDAZINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-02-09 | — | — | EP | disclosed |
| WO-1992019602-A1 | NOVEL PYRIDAZINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1992-11-12 | — | — | WO | disclosed |
| EP-0510562-A1 | Pyridazines | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1992-10-28 | — | — | EP | disclosed |