Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9283497 | 0.85 | HDAC4 (0.36) | HDAC4USP2DRD3TSHRADRA1A | |
| SCHEMBL9280325 | 0.83 | USP2 (0.50) | USP2ALOX15DRD3TSHRMCHR1 | |
| SCHEMBL9278651 | 0.82 | P2RX7 (0.38) | USP2ALOX15CCR1TSHRMCHR1 | |
| SCHEMBL9275586 | 0.82 | HTR1A (0.40) | USP2DRD3TSHRDRD2DRD4 | |
| SCHEMBL9280185 | 0.80 | P2RX7 (0.38) | USP2ALOX15TSHRMCHR1P2RX7 | |
| SCHEMBL9274530 | 0.79 | HRH3 (0.44) | USP2ALOX15TSHR | |
| SCHEMBL9279362 | 0.79 | HDAC8 (0.42) | HDAC4USP2TSHROPRD1 | |
| SCHEMBL9275071 | 0.79 | HRH3 (0.41) | USP2ALOX15TSHRMCHR1P2RX7 | |
| SCHEMBL9275813 | 0.78 | ALDH1A1 (0.37) | HDAC4USP2DRD3TSHRADRA2B | |
| SCHEMBL9281845 | 0.75 | HDAC4 (0.38) | HDAC4DRD3DRD2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | disclosed |