Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | MAOA | P21397 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 6/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15628873 | 0.85 | KDM4E (0.64) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| SCHEMBL13534194 | 0.84 | ALDH1A1 (0.63) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| SCHEMBL7803728 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| Hydrochloric Acid SCHEMBL9224753 | 0.81 | NPC1 (0.44) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| SCHEMBL15623131 | 0.81 | NPC1 (0.44) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| SCHEMBL13533050 | 0.81 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| SCHEMBL11395723 | 0.81 | RAB9A (0.67) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| SCHEMBL13177021 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| SCHEMBL13176725 | 0.79 | ALDH1A1 (0.58) | KDM4EALDH1A1HSD17B10MAOAHPGD | |
| SCHEMBL893303 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10MAOAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173660-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-05-08 | — | — | US | disclosed |
| US-8173660-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-05-08 | — | — | US | disclosed |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-01-06 | — | — | US | disclosed |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-01-06 | — | — | US | disclosed |
| EP-1732558-B1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]- PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-29 | — | — | EP | disclosed |
| EP-1732558-B1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]- PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-29 | — | — | EP | disclosed |
| EP-1781292-B1 | EXTENDED RELEASE FORMULATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1BENZOPYRAN-2-ONE | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-22 | — | — | EP | disclosed |
| EP-1781292-B1 | EXTENDED RELEASE FORMULATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1BENZOPYRAN-2-ONE | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-22 | — | — | EP | disclosed |
| US-7776860-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| US-7776860-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| EP-1732558-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]- PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | Solvay Pharmaceuticals B.V. (NL) | 2006-12-20 | — | — | EP | disclosed |
| WO-2006005760-A1 | EXTENDED RELEASE FORMULATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1BENZOPYRAN-2-ONE | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-01-19 | — | — | WO | disclosed |
| US-20060013874-A1 | Extended release formulation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one | SOLVAY PHARMACEUTICALS B.V. | 2006-01-19 | — | — | US | disclosed |
| WO-2005092340-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005092339-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF MOVEMENT DISORDERS | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005092338-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL) -2H-1-BENZOPYRAN-2-ONE AND SALTS AND HYDRATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | disclosed |
| US-20050215567-A1 | 1-[2H-1-benzopyran-2-one-8-yl]-piperazine derivatives for the treatment of pain | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | disclosed |
| US-20050215551-A1 | 1-[2H-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | disclosed |
| US-20050215566-A1 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | disclosed |
| CN-1105360-A | 1-[2H-1-benzopyran-2-one-8yl]-piperazin derivative | DUPHAR INT RES (NL) | 1995-07-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215551-A1 | 1-[2H-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders | HTR1A, HTR1D, HTR1E | KDM4E 2963/4885ALDH1A1 279/4885HSD17B10 1682/4885 |
| US-20050215566-A1 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | HTR1D, HTR1A, HTR1E | KDM4E 2865/4885ALDH1A1 347/4885HSD17B10 3233/4885 |
| US-20050215567-A1 | 1-[2H-1-benzopyran-2-one-8-yl]-piperazine derivatives for the treatment of pain | HTR1D, HTR1A, HTR5A | KDM4E 3193/4885ALDH1A1 320/4885HSD17B10 3127/4885 |
| US-20060013874-A1 | Extended release formulation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one | SLC18A1, SLC18A2, SLC6A1 | KDM4E 2650/4885ALDH1A1 378/4885HSD17B10 2826/4885 |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | HTR1D, HTR1A, HTR1E | KDM4E 2865/4885ALDH1A1 347/4885HSD17B10 3233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.