Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14016062 | 0.85 | PDE2A (0.42) | PDE2AALDH1A1SLC6A4SLC6A2HTR2A | |
| SCHEMBL30523915 | 0.84 | PDE2A (0.49) | PDE2AALDH1A1SLC6A4HTR2AKCNH2 | |
| SCHEMBL92913 | 0.84 | PDE2A (0.49) | PDE2AALDH1A1SLC6A4HTR2AKCNH2 | |
| SCHEMBL10656350 | 0.83 | SLC6A4 (0.48) | PDE2AALDH1A1SLC6A4SLC6A2HTR2A | |
| SCHEMBL80680 | 0.82 | TRPV1 (0.42) | PDE2AALDH1A1SLC6A4SLC6A2HTR2A | |
| SCHEMBL5436712 | 0.82 | SLC6A4 (0.43) | PDE2AALDH1A1SLC6A4SLC6A2HTR2A | |
| SCHEMBL1014987 | 0.81 | KLF10 (0.44) | PDE2AALDH1A1KLF10CYP3A4FFAR4 | |
| SCHEMBL31085526 | 0.81 | KLF10 (0.44) | PDE2AALDH1A1KLF10CYP3A4FFAR4 | |
| SCHEMBL12512413 | 0.80 | LMNA (0.43) | PDE2AALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL10050765 | 0.80 | SLC6A4 (0.46) | PDE2AALDH1A1SLC6A4SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103265413-A | Synthetic method of 4'-fluorine-2'-methoxyl-5'-isopropy-4-trifloromethyl-1, 1'-biphenyl-2-methanol | UNIV EAST CHINA NORMAL | 2013-08-28 | — | — | CN | claimed |
| CN-103113193-A | Synthetic method of 2-chlorine-5-trifluoromethyl benzyl alcohol | UNIV EAST CHINA NORMAL | 2013-05-22 | — | — | CN | claimed |
| US-9708277-B2 | Inhibitors of cholesterol ester transfer protein | CONCERT PHARMACEUTICALS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9708277-B2 | Inhibitors of cholesterol ester transfer protein | CONCERT PHARMACEUTICALS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| EP-2935508-B1 | TRACERS | RESTRACK AS (NO) | 2017-02-15 | — | — | EP | disclosed |
| US-20160115138-A1 | Inhibitors of Cholesterol Ester Transfer Protein | CONCERT PHARMACEUTICALS, INC. | 2016-04-28 | — | — | US | disclosed |
| US-20160115138-A1 | Inhibitors of Cholesterol Ester Transfer Protein | CONCERT PHARMACEUTICALS, INC. | 2016-04-28 | — | — | US | disclosed |
| EP-2985022-A1 | PROCESS FOR SYNTHESIZING A CETP INHIBITOR | Merck Sharp & Dohme Corp. (US) | 2016-02-17 | — | — | EP | disclosed |
| US-9233938-B2 | Inhibitors of cholesterol ester transfer protein | CONCERT PHARMACEUTICALS, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233938-B2 | Inhibitors of cholesterol ester transfer protein | CONCERT PHARMACEUTICALS, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9212118-B2 | Synthesis of intermediates for preparing anacetrapib and derivatives thereof | LEK PHARMACEUTICALS D.D. (SI) | 2015-12-15 | — | — | US | disclosed |
| US-7192906-B2 | Substituted pyrazole derivatives, production process thereof, and herbicide compositions containing the derivatives | SDS BIOTECH K.K. (JP) | 2007-03-20 | — | — | US | disclosed |
| WO-2007005572-A1 | PROCESS FOR SYNTHESIZING A CETP INHIBITOR | MERCK & CO., INC. (US) | 2007-01-11 | — | — | WO | disclosed |
| EP-0945437-B1 | Pyrazolyl acrylic acid- and pyrazolyl oximino-acetic acid derivatives, their preparation and their use as fungicides | SDS BIOTECH CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-20050014649-A1 | Novel substituted pyrazole derivative, process for producing the same, and herbicidal composition containing the same | SDS BIOTECH K.K. (JP) | 2005-01-20 | — | — | US | disclosed |
| US-6809065-B2 | ON ALGAE OR WEEDS; CROP SELECTIVITY | SDS BIOTECH K.K. (JP) | 2004-10-26 | — | — | US | disclosed |
| EP-1464642-A1 | NOVEL SUBSTITUTED PYRAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND HERBICIDAL COMPOSITION CONTAINING THE SAME | SDS Biotech K.K. (JP) | 2004-10-06 | — | — | EP | disclosed |
| EP-1407667-A1 | HERBICIDE CONTAINING SUBSTITUTED PYRAZOLE DERIVATIVE AS ACTIVE INGREDIENT | SDS Biotech K.K. (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-20040033898-A1 | Herbicide containing substituted pyrazole derivative as active ingredient | SDS BIOTECH K.K. (JP) | 2004-02-19 | — | — | US | disclosed |
| EP-0945437-A1 | Pyrazolyl acrylic acid- and pyrazolyl oximino-acetic acid derivatives, their preparation and their use as fungicides | SDS Biotech K.K. (JP) | 1999-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014649-A1 | Novel substituted pyrazole derivative, process for producing the same, and herbicidal composition containing the same | HPD, HDHD5, CYP2E1 | PDE2A 1754/4885ALDH1A1 296/4885SLC6A4 3676/4885 |
| US-20160115138-A1 | Inhibitors of Cholesterol Ester Transfer Protein | CETP, NPC1L1, STARD3 | PDE2A 3685/4885ALDH1A1 2796/4885SLC6A4 1296/4885 |
| US-20040033898-A1 | Herbicide containing substituted pyrazole derivative as active ingredient | DDT, SULT2A1, CYP2E1 | PDE2A 2905/4885ALDH1A1 365/4885SLC6A4 3216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.