Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549266 | 0.84 | F2 (0.51) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL5050574 | 0.80 | F2 (0.61) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL6297904 | 0.79 | TSHR (0.64) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL9301816 | 0.77 | CA2 (0.62) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL29317752 | 0.76 | F2 (0.45) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL8541021 | 0.76 | FBP1 (0.51) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL23918994 | 0.75 | LMNA (0.65) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL6158564 | 0.75 | MEN1 (0.69) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL15054822 | 0.75 | F2 (0.51) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL8589883 | 0.75 | ALDH1A1 (0.67) | F2PRSS1PRSS2PRSS3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |