Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
| ▸ | C1R | P00736 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28412208 | 0.79 | PSMD14 (0.33) | — | |
| SCHEMBL248855 | 0.79 | NOS1 (0.44) | NOS1CA12CA9DYRK1ACDK9 | |
| SCHEMBL9306986 | 0.76 | ACHE (0.43) | GUSBKMT2A | |
| SCHEMBL20479323 | 0.76 | PDPK1 (0.43) | NOS1CA12CA9DYRK1ACDK9 | |
| SCHEMBL110725 | 0.76 | ALDH1A1 (0.41) | — | |
| SCHEMBL9306736 | 0.76 | CA12 (0.40) | CA12CA9DYRK1ATYMS | |
| SCHEMBL9187598 | 0.76 | MAPT (0.37) | TYMSKMT2A | |
| SCHEMBL9502126 | 0.76 | PARP1 (0.44) | NOS1CA12CA9DYRK1ACDK9 | |
| SCHEMBL18340923 | 0.76 | MASP2 (0.48) | NOS1CA12CA9DYRK1ACDK9 | |
| SCHEMBL17821369 | 0.76 | NOS1 (0.41) | NOS1CA12CA9DYRK1ACDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5347008-A | Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents | CIBA-GEIGY CORPORATION (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0129506-A2 | Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids | CIBA-GEIGY AG (CH) | 1984-12-27 | — | — | EP | disclosed |