Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309904 | 0.92 | MAPK1 (0.36) | MAPK1HSD17B10ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9311392 | 0.90 | AGTR1 (0.38) | MAPK1 | |
| SCHEMBL9308876 | 0.87 | MAPK1 (0.36) | MAPK1HSD17B10ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9310339 | 0.85 | KDM4E (0.33) | MAPK1ALDH1A1SMN1; SMN2KDM4EADORA2B | |
| SCHEMBL9310018 | 0.85 | MAPK1 (0.34) | MAPK1SMN1; SMN2MAPTALOX15TP53 | |
| SCHEMBL9308209 | 0.84 | AGTR1 (0.39) | — | |
| SCHEMBL9310271 | 0.83 | — | — | |
| SCHEMBL9308888 | 0.82 | AGTR1 (0.31) | SMN1; SMN2ADORA2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8545688 | 0.82 | ALDH1A1 (0.38) | MAPK1HSD17B10ALDH1A1MAPTALOX15 | |
| SCHEMBL9309667 | 0.82 | AGTR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |