Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | DAO | P14920 | 1/20 | 0.64 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.64 |
| ▸ | CES2 | O00748 | 3/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL9460609 | 1.00 | TSHR (0.64) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL11650940 | 0.96 | TSHR (0.58) | TSHRDAONAPRTCES2CES1 | |
| Phthalic Acid SCHEMBL5078833 | 0.92 | ALDH1A1 (0.54) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL3384089 | 0.91 | DAO (0.58) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL1969718 | 0.91 | DAO (0.58) | TSHRDAONAPRTCES2CES1 | |
| Terephthalic Acid SCHEMBL2264605 | 0.91 | TSHR (0.60) | TSHRSRD5A2ALDH1A1TP53KMT2A | |
| Benzoic Acid SCHEMBL11359135 | 0.90 | DAO (0.52) | TSHRDAONAPRTCES2CES1 | |
| Isophthalic Acid SCHEMBL1557618 | 0.87 | KMT2A (0.56) | PKMTP53MRGPRX4KMT2ANPC1 | |
| Benzil SCHEMBL2684477 | 0.86 | CES2 (0.64) | CES2CES1ALDH1A1LMNAMAPT | |
| Benzophenone SCHEMBL1147611 | 0.86 | ALDH1A1 (0.64) | CES2CES1SRD5A2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116621910-A | Artificial potassium ion transporter with anti-hepatic fibrosis activity and preparation method and application thereof | 厦门大学 | 2023-08-22 | — | — | CN | claimed |
| CN-102453149-A | Olefin polymerization catalyst component, olefin polymerization catalyst, and olefin polymerization method | CHINA PETROLEUM & CHEMICAL | 2012-05-16 | — | — | CN | claimed |
| EP-1861458-A1 | FLAME RETARDANTS AND FLAME RETARDED POLYMERS | GREAT LAKES CHEMICAL CORPORATION (US) | 2007-12-05 | — | — | EP | claimed |
| WO-2006102138-A1 | FLAME RETARDANTS AND FLAME RETARDED POLYMERS | GREAT LAKES CHEMICAL CORPORATION (US) | 2006-09-28 | — | — | WO | claimed |
| US-6835374-B2 | Fine particle size; mixing, suspension active material with surfactant | REHEIS, INC. | 2004-12-28 | — | — | US | claimed |
| EP-1417953-A2 | Novel antiperspirant/deodorant active for no white residue sticks and soft solids | REHEIS, INC. (US) | 2004-05-12 | — | — | EP | claimed |
| US-20040081632-A1 | Novel antiperspirant/deodorant active for no white residue sticks and soft solids | SUMMIT RESEARCH LABS, INC. | 2004-04-29 | — | — | US | claimed |
| US-4306933-A | Tin/tin-lead stripping solutions | CHEMLINE INDUSTRIES (US) | 1981-12-22 | — | — | US | claimed |
| JP-10044615-A | — | — | None | — | — | JP | disclosed |
| WO-2024071313-A1 | COSMETIC COMPOSITION AND COSMETIC | 株式会社日本触媒 | 2024-04-04 | — | — | WO | disclosed |
| US-20240051979-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2024-02-15 | — | — | US | disclosed |
| US-20240009092-A1 | COSMETIC COMPOSITION AND COSMETIC QUASI-DRUG INCLUDING LIPID PARTICLES CONTAINING PHOSPHOLIPID | NIPPON SHOKUBAI CO., LTD. (JP) | 2024-01-11 | — | — | US | disclosed |
| WO-2023230470-A1 | SURFACTANT COMPRISING POLYOL/ MONOOL - EPOXY PRODUCTS AND ITS PROCESS FOR PREPARATION, COMPOSITION AND METHOD OF USE THEREOF | HERCULES LLC (US) | 2023-11-30 | — | — | WO | disclosed |
| CN-116621910-A | Artificial potassium ion transporter with anti-hepatic fibrosis activity and preparation method and application thereof | 厦门大学 | 2023-08-22 | — | — | CN | disclosed |
| US-5919970-A | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity | ALLERGAN SALES, INC. (US) | 1999-07-06 | — | — | US | disclosed |
| WO-1998048768-A1 | COMPOSITIONS FOR COSMETIC APPLICATIONS | MEDLOGIC GLOBAL CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |
| JP-H1044615-A | MICROCAPSULE COMPOSITION OF THERMAL DEGRADATION PROPERTIES AND HEAT-SENSITIVE MATERIAL | MITSUBISHI PAPER MILLS LTD | 1998-02-17 | — | — | JP | disclosed |
| EP-0409382-A1 | Glutamic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990014340-A1 | GLUTAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-11-29 | — | — | WO | disclosed |
| US-4921836-A | ANTITUMOR AGENTS | BURROUGHS WELLCOME CO. (US) | 1990-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240009092-A1 | COSMETIC COMPOSITION AND COSMETIC QUASI-DRUG INCLUDING LIPID PARTICLES CONTAINING PHOSPHOLIPID | PLIN5, PHOSPHO1, PLIN3 | TSHR 1575/4885DAO 4127/4885NAPRT 1921/4885 |
| US-20240051979-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | TSHR 1445/4885DAO 1459/4885NAPRT 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.