SCHEMBL9319221

SCHEMBL9319221

CCOC(=O)C(c1ccccc1Cl)N(C)C(=O)Cc1c(Cl)cccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 1/20 0.47
SIGMAR1 Q99720 1/20 0.41
AKR1B1 P15121 1/20 0.41
KMT2A Q03164 4/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HTT P42858 1/20 0.39
RORC P51449 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 1/20 0.38
POLB P06746 1/20 0.38
AOC3 Q16853 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9318746 0.88 CASP1 (0.43) CASP1KMT2AMEN1HTTRORC
SCHEMBL9319501 0.87 AKR1B1 (0.44) CASP1SIGMAR1AKR1B1KMT2AMEN1
SCHEMBL8744771 0.86 RORC (0.46) CASP1SIGMAR1AKR1B1KMT2AMEN1
SCHEMBL9321052 0.84 UTS2R (0.42) SIGMAR1AKR1B1KMT2AMEN1NPC1
SCHEMBL9319058 0.84 CCR5 (0.45) CASP1SIGMAR1CYP3A4CYP2C9HTT
SCHEMBL9319787 0.83 AKR1B1 (0.40) SIGMAR1AKR1B1KMT2AMEN1NPC1
SCHEMBL9319470 0.83 OPRM1 (0.49) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL9318635 0.82 ALDH1A1 (0.39) SIGMAR1AKR1B1KMT2AMEN1NPC1
SCHEMBL9318865 0.80 SMN1; SMN2 (0.42) KMT2AMEN1NPC1ALDH1A1POLB
SCHEMBL9319168 0.79 EPHX2 (0.41) CASP1SIGMAR1AKR1B1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5350861-A Insecticides, acaricides, fungicides, antimycotic agents BAYER AKTIENGESELLSCHAFT (DE) 1994-09-27 US disclosed