SCHEMBL9319286

SCHEMBL9319286

FC1(F)C(Cl)=C(Oc2ccccc2)C(F)(F)C1(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 5/20 0.41
TSHR P16473 1/20 0.41
NSD2 O96028 1/20 0.34
HSP90AA1 P07900 1/20 0.34
HKDC1 Q2TB90 1/20 0.34
TLR9 Q9NR96 1/20 0.34
NR1H2 P55055 1/20 0.33
BAX Q07812 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
MAOA P21397 1/20 0.33
DPP4 P27487 1/20 0.33
RAB9A P51151 2/20 0.32
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9364922 0.86 LTA4H (0.50) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL30360063 0.77 LTA4H (0.55) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL9500512 0.74 MAOA (0.45) LTA4HCYP1A2CYP2C9CYP2C19MAOA
SCHEMBL29222726 0.69 LTA4H (0.46) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL9496291 0.67 HSPB1 (0.39) LTA4HMEN1GAAKMT2A
SCHEMBL11744184 0.66
SCHEMBL9498280 0.65 MAPT (0.45) LTA4HTSHRMAOARAB9AMEN1
SCHEMBL9498019 0.65 TEAD4 (0.45) TSHRCYP3A4CYP2C9RAB9AMEN1
SCHEMBL9497570 0.65 MEN1 (0.54) LTA4HNR1H2BAXCYP3A4RAB9A
SCHEMBL9497883 0.65 ALDH1A1 (0.54) TSHRCYP3A4MAOARAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0429998-B1 Process for the preparation of partially fluorinated alcohols BAYER AG (DE) 1994-01-05 EP disclosed
US-5164383-A Insecticides, miticides, nematocides BAYER AKTIENGESELLSCHAFT (DE) 1992-11-17 US disclosed
EP-0507140-A2 O-Halocyclopentyl-S-alkyl-(di)thiophosphoric(phosphonic)-acid ester derivatives, process for their preparation and their use as pesticides BAYER AG (DE) 1992-10-07 EP disclosed
US-5087775-A From halogen-containing alkenes BAYER AKTIENGESELLSCHAFT (DE) 1992-02-11 US disclosed
EP-0429998-A1 Process for the preparation of partially fluorinated alcohols BAYER AG (DE) 1991-06-05 EP disclosed