Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL93191 | 0.88 | HRH3 (0.46) | SIGMAR1HRH3ALDH1A1POLBMAPT | |
| SCHEMBL6652887 | 0.80 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1POLBMAPT | |
| SCHEMBL6446179 | 0.80 | GLA (0.40) | ALDH1A1TSHR | |
| SCHEMBL93165 | 0.76 | HRH3 (0.37) | SIGMAR1HRH3ALDH1A1POLBMAPT | |
| SCHEMBL10501124 | 0.75 | L3MBTL1 (0.41) | SIGMAR1HRH3ALDH1A1POLBMAPT | |
| SCHEMBL24891390 | 0.75 | HRH3 (0.48) | SIGMAR1HRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL791946 | 0.75 | SIGMAR1 (0.58) | SIGMAR1SLC6A2SLC6A4SLC6A3GRIN2D | |
| SCHEMBL24891389 | 0.75 | HRH3 (0.48) | SIGMAR1HRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24891404 | 0.75 | HRH3 (0.48) | SIGMAR1HRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9927903 | 0.75 | HRH3 (0.48) | SIGMAR1HRH3SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10584128-B2 | Bicyclic dihydropyrimidine-carboxamide derivatives as Rho-Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-03-10 | — | — | US | claimed |
| EP-3558999-A1 | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2019-10-30 | — | — | EP | claimed |
| CN-110062758-A | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS | 奇斯药制品公司 | 2019-07-26 | — | — | CN | claimed |
| WO-2018115383-A1 | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-06-28 | — | — | WO | claimed |
| US-20180170939-A1 | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTISI S.p.A. (IT) | 2018-06-21 | — | — | US | claimed |
| US-11725007-B2 | Meta tyrosine derivatives as rho-kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-08-15 | — | — | US | disclosed |
| US-11578068-B2 | Oxadiazole derivatives as Rho-Kinase Inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-02-14 | — | — | US | disclosed |
| US-11332468-B2 | Azaindole derivatives as Rho-kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-05-17 | — | — | US | disclosed |
| EP-3728248-B1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2022-02-02 | — | — | EP | disclosed |
| US-11147812-B2 | Tyrosine analogues derivatives as Rho-kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-10-19 | — | — | US | disclosed |
| EP-3728246-B1 | META TYROSINE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-09-22 | — | — | EP | disclosed |
| EP-3728247-B1 | OXADIAZOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-09-22 | — | — | EP | disclosed |
| EP-2426488-B1 | MEASUREMENT METHOD UTILIZING INTERNAL STANDARD SUBSTANCE | WAKO PURE CHEM IND LTD (JP) | 2016-04-20 | — | — | EP | disclosed |
| EP-2426123-B1 | PYRAZOLE-BASED CYANINE DYE CONTAINING QUATERNARY AMMONIUM CATION | WAKO PURE CHEM IND LTD (JP) | 2014-08-06 | — | — | EP | disclosed |
| US-8663990-B2 | Measurement method utilizing internal standard substance | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2014-03-04 | — | — | US | disclosed |
| US-8546586-B2 | Pyrazole-based cyanine dye containing quaternary ammonium cation | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2013-10-01 | — | — | US | disclosed |
| EP-2426488-A1 | MEASUREMENT METHOD UTILIZING INTERNAL STANDARD SUBSTANCE | Wako Pure Chemical Industries, Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |
| EP-2426123-A1 | PYRAZOLE-BASED CYANINE DYE CONTAINING QUATERNARY AMMONIUM CATION | Wako Pure Chemical Industries, Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20120046474-A1 | PYRAZOLE-BASED CYANINE DYE CONTAINING QUATERNARY AMMONIUM CATION | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2012-02-23 | — | — | US | disclosed |
| US-20120043207-A1 | MEASUREMENT METHOD UTILIZING INTERNAL STANDARD SUBSTANCE | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11147812-B2 | Tyrosine analogues derivatives as Rho-kinase inhibitors | ROCK1, ROCK2, RHOA | SIGMAR1 3791/4885HRH3 643/4885ALDH1A1 2989/4885 |
| US-20180170939-A1 | BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, CIT | SIGMAR1 4129/4885HRH3 668/4885ALDH1A1 1519/4885 |
| US-11332468-B2 | Azaindole derivatives as Rho-kinase inhibitors | ROCK1, ROCK2, RHOA | SIGMAR1 3760/4885HRH3 495/4885ALDH1A1 2242/4885 |
| US-20120046474-A1 | PYRAZOLE-BASED CYANINE DYE CONTAINING QUATERNARY AMMONIUM CATION | SLC43A1, HCN4, SLC7A5 | SIGMAR1 57/4885HRH3 197/4885ALDH1A1 1828/4885 |
| US-11578068-B2 | Oxadiazole derivatives as Rho-Kinase Inhibitors | ROCK1, ROCK2, RHOA | SIGMAR1 3460/4885HRH3 710/4885ALDH1A1 1471/4885 |
| US-11725007-B2 | Meta tyrosine derivatives as rho-kinase inhibitors | ROCK1, ROCK2, RHOA | SIGMAR1 3649/4885HRH3 616/4885ALDH1A1 3053/4885 |
| US-10584128-B2 | Bicyclic dihydropyrimidine-carboxamide derivatives as Rho-Kinase inhibitors | ROCK1, ROCK2, CIT | SIGMAR1 4129/4885HRH3 668/4885ALDH1A1 1519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.