Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9324433 | 0.92 | SIGMAR1 (0.39) | HTR2ADRD2DRD3SIGMAR1MAPT | |
| SCHEMBL9327453 | 0.83 | KCNH2 (0.55) | DRD2DRD3SIGMAR1THRATHRB | |
| SCHEMBL9326153 | 0.81 | DRD2 (0.37) | HTR2ADRD2DRD3SIGMAR1MAPT | |
| SCHEMBL10529039 | 0.76 | MAPT (0.46) | HTR2ATHRATHRBMAPTKCNH2 | |
| SCHEMBL9326394 | 0.75 | LTA4H (0.41) | HTR2ADRD2DRD3MAPTKCNH2 | |
| SCHEMBL9327633 | 0.75 | KCNH2 (0.50) | SIGMAR1MAPTKCNH2ALDH1A1 | |
| SCHEMBL9327577 | 0.74 | DRD3 (0.54) | DRD2DRD3MAPTKCNH2MAOB | |
| SCHEMBL10529828 | 0.72 | HTR2A (0.45) | HTR2ATHRATHRBMAPTKCNH2 | |
| SCHEMBL9325409 | 0.71 | TDP1 (0.40) | HTR2ADRD2DRD3MAPTKCNH2 | |
| SCHEMBL9326409 | 0.71 | SIGMAR1 (0.39) | DRD2DRD3SIGMAR1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |