Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325455 | 0.92 | HTR2A (0.39) | SIGMAR1DRD2DRD3MAOBTAAR1 | |
| SCHEMBL9326153 | 0.85 | DRD2 (0.37) | SIGMAR1DRD2DRD3MAOBTAAR1 | |
| SCHEMBL9326394 | 0.83 | LTA4H (0.41) | DRD2DRD3OPRK1KCNH2CYP3A4 | |
| SCHEMBL9327633 | 0.83 | KCNH2 (0.50) | SIGMAR1KCNH2TSHRMAPT | |
| SCHEMBL9324382 | 0.81 | KDM4E (0.39) | SIGMAR1DRD3KCNH2ADRA2BADRA2C | |
| SCHEMBL9325409 | 0.80 | TDP1 (0.40) | DRD2DRD3OPRK1KCNH2CYP3A4 | |
| SCHEMBL9326409 | 0.80 | SIGMAR1 (0.39) | SIGMAR1DRD2DRD3MAOBTAAR1 | |
| SCHEMBL9325440 | 0.79 | TAAR1 (0.43) | DRD2DRD3TAAR1OPRK1OPRM1 | |
| SCHEMBL9327577 | 0.77 | DRD3 (0.54) | DRD2DRD3MAOBTAAR1KCNH2 | |
| SCHEMBL9327453 | 0.75 | KCNH2 (0.55) | SIGMAR1DRD2DRD3KCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |