Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325778 | 0.81 | KCNH2 (0.67) | DRD3DRD2KCNH2 | |
| SCHEMBL5632446 | 0.81 | KCNH2 (0.56) | DRD3KCNH2CHRM2HTR1AADRA2A | |
| SCHEMBL22403770 | 0.79 | KCNH2 (0.66) | DRD3KCNH2CHRM2HTR1AADRA2A | |
| SCHEMBL9630022 | 0.79 | GFER (0.54) | DRD3KCNH2CHRM2HTR1AADRA2A | |
| SCHEMBL9624160 | 0.78 | KCNH2 (0.62) | DRD3DRD2KCNH2CHRM2HTR1A | |
| SCHEMBL10530872 | 0.78 | KCNH2 (0.71) | DRD3KCNH2CHRM2HTR1AADRA2A | |
| SCHEMBL9324433 | 0.77 | SIGMAR1 (0.39) | DRD3DRD2KCNH2HTR1AADRA2A | |
| SCHEMBL12156482 | 0.76 | KCNH2 (0.60) | DRD3KCNH2CHRM2HTR1AADRA2A | |
| SCHEMBL3161700 | 0.75 | GFER (0.54) | DRD3KCNH2CHRM2HTR1AADRA2A | |
| SCHEMBL9326153 | 0.74 | DRD2 (0.37) | DRD3DRD2KCNH2OPRM1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |