Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327189 | 0.84 | ADORA3 (0.61) | ADORA3ADORA2AADORA2BMAPTMEN1 | |
| SCHEMBL9329238 | 0.78 | ADORA2A (0.72) | ADORA3ADORA2AADORA2B | |
| SCHEMBL9328560 | 0.72 | ADORA3 (0.58) | ADORA3ADORA2AADORA2BKLKB1KLK1 | |
| SCHEMBL9328936 | 0.71 | ADORA3 (0.42) | ADORA3ADORA2AADORA2BMAPTTP53 | |
| SCHEMBL30596780 | 0.69 | KDM4E (0.41) | ADORA3ADORA2AADORA2BMAPTHPGD | |
| SCHEMBL30596777 | 0.69 | KDM4E (0.41) | ADORA3ADORA2AADORA2BMAPTHPGD | |
| SCHEMBL9328796 | 0.69 | ADORA2A (0.69) | ADORA3ADORA2AADORA2B | |
| SCHEMBL9327253 | 0.68 | ADORA2A (0.48) | ADORA3ADORA2AADORA2BSMN1; SMN2HDAC6 | |
| SCHEMBL7304349 | 0.67 | RAB9A (0.47) | ADORA3KLKB1KLK1MAPTMEN1 | |
| SCHEMBL7301901 | 0.67 | DHPS (0.53) | ADORA3NPC1RAB9ASMN1; SMN2RPS6KB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356894-A | Adenosine antagonists | SYNGENTA LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| US-5270311-A | [1,2,4]-Triazolo[1,5-a]and pyrazolo[2,3-a][1,3,5]triazine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-14 | — | — | US | disclosed |
| EP-0459702-A1 | Azole Derivatives | ZENECA LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |