SCHEMBL9336288

SCHEMBL9336288

O=C(Br)c1ccc(-c2nc(C(Cl)(Cl)Cl)nc(C(Cl)(Cl)Cl)n2)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
HDAC6 Q9UBN7 4/20 0.31
KDM4E B2RXH2 4/20 0.31
HDAC4 P56524 2/20 0.31
ALDH1A1 P00352 2/20 0.31
HPGD P15428 2/20 0.31
TP53 P04637 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
HIF1A Q16665 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
PLK1 P53350 1/20 0.31
HDAC3 O15379 1/20 0.31
NCOR2 Q9Y618 1/20 0.31
ADORA3 P0DMS8 2/20 0.31
MAP4K4 O95819 1/20 0.30
MAPT P10636 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
NPC1 O15118 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1936088 0.84 TSHR (0.44) MEN1KMT2AKDM4EALDH1A1TP53
SCHEMBL9015250 0.84 ALDH1A1 (0.36) MEN1KMT2AKDM4EHDAC4ALDH1A1
SCHEMBL8412982 0.82 NPC1 (0.38) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL125046 0.82 ADORA3 (0.46) MEN1KMT2AHDAC6KDM4EALDH1A1
SCHEMBL12952337 0.81 PLK1 (0.51) MEN1KMT2AHDAC6HDAC4HPGD
SCHEMBL7746430 0.78 MAPT (0.47) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL14138137 0.78 ABCC4 (0.49)
SCHEMBL8607879 0.77 MEN1 (0.48) MEN1KMT2AALDH1A1HPGDTP53
SCHEMBL130297 0.77 NR1H4 (0.39) MEN1KMT2AKDM4EALDH1A1RXFP1
SCHEMBL12922922 0.77 PTPN1 (0.61) HDAC6KDM4EHDAC4ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0332042-B1 Aromatic compounds substituted by 4,6-bis-trichloromethyl-s-triazin-2-yl groups, process for their preparation and their use in photosensitive mixtures HOECHST AG (DE) 1994-05-25 EP disclosed
US-5064959-A Photoinitiators HOECHST AKTIENGESELLSCHAFT (DE) 1991-11-12 US disclosed
EP-0332042-A1 Aromatic compounds substituted by 4,6-bis-trichloromethyl-s-triazin-2-yl groups, process for their preparation and their use in photosensitive mixtures HOECHST AKTIENGESELLSCHAFT (DE) 1989-09-13 EP disclosed