SCHEMBL7746430

SCHEMBL7746430

COC(=O)c1ccc(-c2nc(C(Cl)(Cl)Cl)nc(C(Cl)(Cl)Cl)n2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.47
ALDH1A1 P00352 6/20 0.47
KDM4E B2RXH2 5/20 0.47
RAB9A P51151 4/20 0.47
SMN1; SMN2 Q16637 4/20 0.47
NPC1 O15118 3/20 0.47
HPGD P15428 3/20 0.47
HSD17B10 Q99714 2/20 0.47
CA1 P00915 3/20 0.46
CA2 P00918 3/20 0.46
CA12 O43570 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
CA7 P43166 1/20 0.46
LMNA P02545 2/20 0.46
MEN1 O00255 1/20 0.46
GAA P10253 1/20 0.46
KMT2A Q03164 1/20 0.46
NFKB1 P19838 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL124262 0.83 CA12 (0.50) MAPTALDH1A1KDM4ERAB9ASMN1; SMN2
SCHEMBL9873018 0.83 TSHR (0.42) MAPTALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL7747047 0.82 SDHB (0.50) RAB9ANPC1CA1CA2CA12
SCHEMBL125046 0.81 ADORA3 (0.46) MAPTALDH1A1KDM4ERAB9ASMN1; SMN2
SCHEMBL9872065 0.81 ALDH1A1 (0.53) MAPTALDH1A1KDM4ERAB9ASMN1; SMN2
SCHEMBL12952337 0.81 PLK1 (0.51) MAPTRAB9ASMN1; SMN2NPC1HPGD
SCHEMBL9872852 0.80 TSHR (0.37) MAPTALDH1A1KDM4ERAB9ASMN1; SMN2
SCHEMBL1936088 0.80 TSHR (0.44) ALDH1A1KDM4ERAB9ASMN1; SMN2NPC1
SCHEMBL9015250 0.80 ALDH1A1 (0.36) MAPTALDH1A1KDM4ERAB9ASMN1; SMN2
SCHEMBL126667 0.79 PARP10 (0.45) MAPTALDH1A1RAB9ASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120295204-A1 PROCESSING METHOD OF LITHOGRAPHIC PRINTING PLATE PREURSOR FUJIFILM CORPORATION (JP) 2012-11-22 US disclosed
US-20100016465-A1 Composite Material Comprising A Water-Or Acid-Releasing Agent DENTOFIT A/S (DK) 2010-01-21 US disclosed
US-20100016465-A1 Composite Material Comprising A Water-Or Acid-Releasing Agent DENTOFIT A/S (DK) 2010-01-21 US disclosed
US-20080199811-A1 PHOTOSENSITIVE COMPOSITION AND TWO-PHOTON ABSORPTION PHOTORECORDING MEDIUM FUJIFILM CORPORATION (JP) 2008-08-21 US disclosed
WO-2007104312-A2 COMPOSITE MATERIAL, IN PARTICULAR A DENTAL FILLING MATERIAL DENTOFIT A/S (DK) 2007-09-20 WO disclosed
US-6190833-B1 (A) A PHENOL RESIN, (B) AN AMINO RESIN, (C) A COMPOUND HAVING TWO OR MORE CROSSLINKING GROUPS IN A MOLECULE, AND (D) A HALOMETHYL-1,3,5-TRIAZINE COMPOUND. JSR CORPORATION (JP) 2001-02-20 US disclosed
EP-0412570-B1 Light- and heat-sensitive recording material FUJI PHOTO FILM CO LTD (JP) 1996-07-10 EP disclosed
US-5216158-A Oxadiazole compounds containing 4,6-bis-trichloromethyl-S-triazin-2-yl groups, process for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-01 US disclosed
US-5091280-A Photothermography; microencapsulated leuco dyes, polymerizable vinyl monomer, photoinitiator electron acceptive developer FUJI PHOTO FILM CO., LTD. (JP) 1992-02-25 US disclosed
US-5064959-A Photoinitiators HOECHST AKTIENGESELLSCHAFT (DE) 1991-11-12 US disclosed
EP-0412570-A2 Light- and heat-sensitive recording material FUJI PHOTO FILM CO., LTD. (JP) 1991-02-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016465-A1 Composite Material Comprising A Water-Or Acid-Releasing Agent PLA2G2C, SMARCA1, VMA21 MAPT 1497/4885ALDH1A1 1006/4885KDM4E 2790/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.