Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 1.00 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | ACHE | P22303 | 3/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | AKT2 | P31751 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.53 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.53 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13720053 | 1.00 | IKBKB (1.00) | IKBKBHSD11B1MEN1KMT2AFGFR1 | |
| SCHEMBL932826 | 1.00 | IKBKB (1.00) | IKBKBHSD11B1MEN1KMT2AFGFR1 | |
| SCHEMBL4463213 | 0.80 | KMT2A (1.00) | IKBKBHSD11B1MEN1KMT2AFGFR1 | |
| SCHEMBL21166873 | 0.80 | IKBKB (0.67) | IKBKBHSD11B1MEN1KMT2AFGFR1 | |
| SCHEMBL29497271 | 0.80 | HSD11B1 (1.00) | IKBKBHSD11B1MEN1KMT2AMAPK1 | |
| SCHEMBL4463210 | 0.80 | KMT2A (1.00) | IKBKBHSD11B1MEN1KMT2AFGFR1 | |
| SCHEMBL13719949 | 0.80 | IKBKB (0.67) | IKBKBMEN1KMT2AFGFR1ACHE | |
| SCHEMBL21166874 | 0.80 | IKBKB (0.67) | IKBKBHSD11B1MEN1KMT2AFGFR1 | |
| SCHEMBL13719950 | 0.80 | IKBKB (0.67) | IKBKBMEN1KMT2AFGFR1ACHE | |
| SCHEMBL14820391 | 0.80 | KMT2A (1.00) | IKBKBHSD11B1MEN1KMT2AFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590147-B1 | Spirooxindole-pyrrolothiazole heterocyclic hybrids | KING SAUD UNIVERSITY (SA) | 2020-03-17 | — | — | US | claimed |
| CN-118027110-A | 3, 5-Bis (4-substituent benzylidene) piperidin-4-one-platinum complex and preparation method and application thereof | 桂林医学院 | 2024-05-14 | — | — | CN | disclosed |
| CN-115260212-B | 3, 5-bis (benzylidene) -4-piperidone derivative as well as preparation method and application thereof | 桂林医学院 | 2023-05-23 | — | — | CN | disclosed |
| CN-115260212-A | 3, 5-bis (benzylidene) -4-piperidone derivative and preparation method and application thereof | 桂林医学院 | 2022-11-01 | — | — | CN | disclosed |
| US-10590147-B1 | Spirooxindole-pyrrolothiazole heterocyclic hybrids | KING SAUD UNIVERSITY (SA) | 2020-03-17 | — | — | US | disclosed |
| US-9359196-B2 | Antiproliferative compositions comprising curcumin analogs and methods of producing and using same | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2016-06-07 | — | — | US | disclosed |
| US-20120316203-A1 | Compositions and Methods for Inhibition of Cancers | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120288555-A1 | ANTIPROLIFERATIVE COMPOSITIONS COMPRISING CURCUMIN ANALOGS AND METHODS OF PRODUCING AND USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2012-11-15 | — | — | US | disclosed |
| EP-2451273-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF CANCERS | The Ohio State University Research Foundation (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005790-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF CANCERS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316203-A1 | Compositions and Methods for Inhibition of Cancers | HCCS, GPX4, HMOX1 | IKBKB 2646/4885HSD11B1 2079/4885MEN1 3347/4885 |
| US-10590147-B1 | Spirooxindole-pyrrolothiazole heterocyclic hybrids | BRD9, BRWD1, BRD7 | IKBKB 2776/4885HSD11B1 2499/4885MEN1 2262/4885 |
| US-20120288555-A1 | ANTIPROLIFERATIVE COMPOSITIONS COMPRISING CURCUMIN ANALOGS AND METHODS OF PRODUCING AND USING SAME | MCL1, LITAF, CTSA | IKBKB 3061/4885HSD11B1 4453/4885MEN1 1097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.