Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3906851 | 0.92 | RAPGEF4 (0.50) | RAPGEF4TRPV4L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL20182638 | 0.85 | TSHR (0.44) | RAPGEF4TRPV4TSHRKMT2AMAPT | |
| SCHEMBL8665535 | 0.84 | TRPV4 (0.32) | RAPGEF4TRPV4L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL8496162 | 0.84 | CYP3A4 (0.48) | RAPGEF4TRPV4L3MBTL1TSHRALDH1A1 | |
| SCHEMBL17203385 | 0.84 | L3MBTL1 (0.51) | RAPGEF4TRPV4L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL26512818 | 0.82 | TRPV4 (0.38) | RAPGEF4TRPV4L3MBTL1TSHRKMT2A | |
| SCHEMBL29707985 | 0.80 | SOD1 (0.47) | L3MBTL1TSHRMEN1KMT2ALMNA | |
| SCHEMBL17056174 | 0.80 | PTGS2 (0.33) | RAPGEF4TRPV4L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL152556 | 0.80 | SOD1 (0.47) | L3MBTL1TSHRMEN1KMT2ALMNA | |
| SCHEMBL4616550 | 0.80 | ALDH1A1 (0.47) | L3MBTL1SMN1; SMN2ALDH1A1GAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| EP-0307879-B1 | Sulfonamido derivatives inhibiting the aldose reductase enzyme system and pharmaceutical compositions containing them | BALDACCI LAB SPA (IT) | 1994-06-01 | — | — | EP | disclosed |
| US-5066676-A | Reducing vision problems related to diabetes | LABORATORI BALDACCI SPA (IT) | 1991-11-19 | — | — | US | disclosed |
| US-4927849-A | TREATMENT OF DIABETES COMPLICATIONS | LABORATORI BALDACCI SPA (IT) | 1990-05-22 | — | — | US | disclosed |
| EP-0307879-A2 | Sulfonamido derivatives inhibiting the aldose reductase enzyme system and pharmaceutical compositions containing them | LABORATORI BALDACCI Spa (IT) | 1989-03-22 | — | — | EP | disclosed |
| EP-0142805-A2 | Aminoplast curable compositions containing disulfonic acid esters as latent acid catalysts | PPG INDUSTRIES, INC. (US) | 1985-05-29 | — | — | EP | disclosed |
| US-4501854-A | FILMS, COATINGS, PAINTS, MOLDINGS, LAMINATES | PPG INDUSTRIES, INC. (US) | 1985-02-26 | — | — | US | disclosed |
| US-4438245-A | FOR LIGHT SENSITIVE ELEMENTS | FUJI PHOTO FILM CO., LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
| US-4370430-A | PIPERIDYL-CONTAINING SULFONAMIDE OLIGOMER | AMERICAN CYANAMID COMPANY (US) | 1983-01-25 | — | — | US | disclosed |
| US-4209632-A | BLOWING AGENTS | UNIROYAL, INC. (US) | 1980-06-24 | — | — | US | disclosed |
| US-4135049-A | SULFONYL CARBAZATES AS BLOWING AGENTS | UNIROYAL, INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4133832-A | Blowing agents -bis(hydrocarbylsulfonyl) carbohydrazides | UNIROYAL, INC. (US) | 1979-01-09 | — | — | US | disclosed |
| US-4096100-A | Blowing agents-bis(hydrocarbylsulfonyl) carbohydrazides | UNIROYAL, INC. (US) | 1978-06-20 | — | — | US | disclosed |
| US-4012432-A | Sulfonyl carbazates as blowing agents | UNIROYAL INC. (US) | 1977-03-15 | — | — | US | disclosed |