SCHEMBL9339552

SCHEMBL9339552

N#Cc1cc(F)c(Br)c(F)c1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.46
ALB P02768 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
TRPV4 Q9HBA0 3/20 0.36
KDM1A O60341 2/20 0.35
KDM1B Q8NB78 1/20 0.35
HTT P42858 1/20 0.34
KIF11 P52732 1/20 0.34
EGLN2 Q96KS0 5/20 0.34
VCAM1 P19320 1/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20912550 0.78 TTR (0.52) TTRALBMEN1KMT2ATRPV4
SCHEMBL30297979 0.78 TTR (0.52) TTRALBMEN1KMT2ATRPV4
SCHEMBL31485922 0.78 MAP2K1 (0.40) TTRALBMEN1KMT2AHTT
SCHEMBL157603 0.78 CES2 (0.42) TTRALBMEN1KMT2ATRPV4
SCHEMBL30372844 0.77 VCAM1 (0.56) MEN1KMT2AVCAM1
SCHEMBL6649045 0.76 TRPV4 (0.61) TTRALBMEN1KMT2ATRPV4
SCHEMBL29710965 0.75 TRPV4 (0.43) MEN1KMT2ATRPV4CYP11B1CYP11B2
SCHEMBL14247428 0.75 MEN1 (0.48) TTRALBMEN1KMT2AHTT
SCHEMBL8773853 0.75 TTR (0.72) TTRALBMEN1KMT2AHTT
SCHEMBL198609 0.74 TTR (0.52) TTRALBMEN1KMT2ATRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12486449-B2 Organic molecules for use in organic optoelectronic devices SAMSUNG DISPLAY CO., LTD. (KR) 2025-12-02 US disclosed
US-20250170248-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-05-29 US disclosed
US-20250115608-A1 HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS ARDELYX, INC. (US) 2025-04-10 US disclosed
US-12209088-B2 Hormone receptor modulators for treating metabolic conditions and disorders ARDELYX, INC. (US) 2025-01-28 US disclosed
US-12122749-B2 Heterocyclic compound and organic light-emitting device comprising same SAMSUNG DISPLAY CO., LTD. (KR) 2024-10-22 US disclosed
CN-107531698-B Fused bicyclic heteroaryl derivatives having activity as PHD inhibitors 武田药品工业株式会社 2024-08-13 CN disclosed
EP-4363425-A1 SMARCA DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2024-05-08 EP disclosed
WO-2023239645-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-12-14 WO disclosed
WO-2023239645-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-12-14 WO disclosed
CN-114634512-B Compounds as inhibitors of bruton's tyrosine kinase, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2023-11-14 CN disclosed
EP-0391591-B1 Pyrimidine derivative and liquid crystal composition incorporating the same SEIKO EPSON CORP (JP) 1994-06-15 EP disclosed
EP-0390329-B1 Pyrimidine derivative SEIKO EPSON CORP (JP) 1993-12-01 EP disclosed
EP-0317175-B1 PYRIMIDINE DERIVATIVES SEIKO EPSON CORPORATION (JP) 1993-09-22 EP disclosed
US-5200110-A Electro-optical displays; heat resistance, dielectrics, low driving voltage, dielectrics SEIKO EPSON CORPORATION (JP) 1993-04-06 US disclosed
EP-0447565-A1 1,3-DIOXANE DERIVATIVE AND LIQUID-CRYSTAL COMPOSITION CONTAINING THE SAME SEIKO EPSON CORPORATION (JP) 1991-09-25 EP disclosed
US-5030382-A Liquid crystals SEIKO EPSON CORPORATION (JP) 1991-07-09 US disclosed
EP-0391591-A2 Pyrimidine derivative and liquid crystal composition incorporating the same SEIKO EPSON CORPORATION (JP) 1990-10-10 EP disclosed
EP-0390329-A1 Pyrimidine derivative SEIKO EPSON CORPORATION (JP) 1990-10-03 EP disclosed
US-4883609-A LIQUID CRYSTALS SEIKO EPSON CORPORATION (JP) 1989-11-28 US disclosed
EP-0317175-A2 Pyrimidine derivatives SEIKO EPSON CORPORATION (JP) 1989-05-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12209088-B2 Hormone receptor modulators for treating metabolic conditions and disorders NR1H4, FXR1, GLP1R TTR 2475/4885ALB 1992/4885MEN1 343/4885
US-20250170248-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCA2, SMARCC2 TTR 4658/4885ALB 4771/4885MEN1 2085/4885
US-12486449-B2 Organic molecules for use in organic optoelectronic devices OR10J3, OR51E2, OCIAD2 TTR 999/4885ALB 2056/4885MEN1 2119/4885
US-12122749-B2 Heterocyclic compound and organic light-emitting device comprising same CCND2, CCND1, CRY1 TTR 3921/4885ALB 3039/4885MEN1 438/4885
US-20250115608-A1 HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS NR1H4, FXR1, GLP1R TTR 2475/4885ALB 1992/4885MEN1 343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.