Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | VNN1 | O95497 | 1/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934511 | 0.87 | VNN1 (0.58) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL6695006 | 0.85 | MAPT (0.68) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL24097464 | 0.85 | MAPT (0.68) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL6691560 | 0.82 | NOS1 (0.58) | MAPTKDM4EALDH1A1NOS1HDAC4 | |
| SCHEMBL1680823 | 0.81 | LMNA (0.57) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL30373777 | 0.81 | HIF1A (0.76) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL1134085 | 0.81 | HIF1A (0.76) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL34462781 | 0.80 | CLK4 (0.56) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5181482 | 0.80 | HDAC1 (0.48) | MAPTMEN1KMT2AHIF1ANOS1 | |
| SCHEMBL7152039 | 0.80 | VNN1 (0.61) | MAPTKDM4EALDH1A1GAAVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454243-A2 | TETRAZOLE DERIVATIVES | Merck Serono SA (CH) | 2012-05-23 | — | — | EP | disclosed |
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | TSLP, IL5, CMA1 | MAPT 1446/4885KDM4E 3121/4885ALDH1A1 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.