Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 10/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 1/20 | 0.39 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9332530 | 0.91 | KEAP1 (0.47) | CHRM3KEAP1SMN1; SMN2CHRM1PRMT3 | |
| Oxalic Acid SCHEMBL9345651 | 0.89 | PRMT3 (0.47) | CHRM3SMN1; SMN2MEN1KMT2AARG1 | |
| Oxalic Acid SCHEMBL9345679 | 0.82 | ARG1 (0.44) | CHRM3KEAP1SMN1; SMN2KMT2AARG1 | |
| SCHEMBL6783180 | 0.79 | ALOX15 (0.52) | CHRM3ARG1ARG2PRMT3CARM1 | |
| SCHEMBL3898311 | 0.79 | CYP1A2 (0.58) | CHRM3SMN1; SMN2CHRM1ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL26088474 | 0.77 | GNAO1 (0.50) | CHRM3ARG1ARG2PRMT3CARM1 | |
| SCHEMBL3847073 | 0.77 | CYP1A2 (0.52) | SMN1; SMN2ACHEHRH3 | |
| SCHEMBL6327507 | 0.77 | ACHE (0.45) | CHRM3KEAP1SMN1; SMN2MEN1KMT2A | |
| Oxalic Acid SCHEMBL9349126 | 0.76 | PRMT3 (0.45) | CHRM3MEN1KMT2ACHRM1PRMT3 | |
| SCHEMBL3424493 | 0.76 | HRH3 (0.42) | CHRM3MEN1KMT2ACHRM1ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |