Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934853 | 1.00 | ALOX5 (0.56) | ALOX5ALDH1A1PTGS2NPC1RAB9A | |
| SCHEMBL1629179 | 0.89 | ALDH1A1 (0.53) | ALOX5ALDH1A1PTGS2NPC1RAB9A | |
| SCHEMBL1629181 | 0.89 | ALDH1A1 (0.53) | ALOX5ALDH1A1PTGS2NPC1RAB9A | |
| SCHEMBL9900542 | 0.89 | ALDH1A1 (0.53) | ALOX5ALDH1A1PTGS2NPC1RAB9A | |
| SCHEMBL2047156 | 0.88 | NPC1 (0.50) | ALOX5ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL2047154 | 0.88 | NPC1 (0.50) | ALOX5ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL408659 | 0.86 | ALDH1A1 (0.50) | ALOX5ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL408656 | 0.86 | ALDH1A1 (0.50) | ALOX5ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL9898660 | 0.84 | ALDH1A1 (0.49) | ALOX5ALDH1A1PTGS2NPC1RAB9A | |
| SCHEMBL9898661 | 0.84 | ALDH1A1 (0.49) | ALOX5ALDH1A1PTGS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130708-A9 | BETA-LACTAMASE INHIBITORS | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2011-01-13 | — | — | WO | disclosed |
| WO-2010130708-A1 | BETA-LACTAMASE INHIBITORS | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292185-A1 | BETA-LACTAMASE INHIBITORS | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD (BM) | 2010-11-18 | — | — | US | disclosed |
| US-7589159-B2 | Process for producing radical polymer | TECHNO NETWORK SHIKOKU CO., LTD. (JP) | 2009-09-15 | — | — | US | disclosed |
| US-20070032615-A1 | Process for producing radical polymer | TECHNO NETWORK SHIKOKU CO., LTD. (JP) | 2007-02-08 | — | — | US | disclosed |
| EP-0048911-B1 | O-SUBSTITUTED OXIMES OF ALPHA-KETOCARBOXYLIC ACID, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | Roche Diagnostics GmbH (DE) | 1984-12-05 | — | — | EP | disclosed |
| US-4425360-A | Pharmacologically active novel O-substituted pyruvic acid oximes | BOEHRINGER MANNHEIM GMBH (DE) | 1984-01-10 | — | — | US | disclosed |
| EP-0048911-A2 | O-substituted oximes of alpha-ketocarboxylic acid, preparation and pharmaceutical compositions | Roche Diagnostics GmbH (DE) | 1982-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292185-A1 | BETA-LACTAMASE INHIBITORS | GANAB, BPGM, BLVRB | ALOX5 1280/4885ALDH1A1 430/4885PTGS2 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.