Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386614 | 0.83 | LMNA (0.47) | ALDH1A1MEN1CYP1A2KMT2AKDM4E | |
| SCHEMBL9386270 | 0.82 | MMP13 (0.44) | ALDH1A1HPGDTSHRMMP13CYP1A2 | |
| SCHEMBL9379647 | 0.79 | ALOX15 (0.42) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL9642484 | 0.78 | MMP13 (0.38) | ALDH1A1HPGDTSHRMMP13CYP1A2 | |
| SCHEMBL9381350 | 0.77 | ALOX15 (0.55) | ALDH1A1MEN1CYP1A2KMT2ARAB9A | |
| SCHEMBL9383893 | 0.76 | PDGFRB (0.42) | ARMEN1CYP1A2KMT2AKDM4E | |
| SCHEMBL7218028 | 0.72 | ALDH1A1 (0.76) | ALDH1A1HPGDTSHRARNPC1 | |
| SCHEMBL9383828 | 0.70 | PTGDR (0.48) | TSHRMEN1CYP1A2KMT2AKDM4E | |
| SCHEMBL9382878 | 0.69 | LMNA (0.54) | ALDH1A1HPGDTSHRMEN1CYP1A2 | |
| SCHEMBL20877150 | 0.67 | MMP13 (0.46) | ALDH1A1HPGDMMP13MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398283-B1 | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5112821-A | Excitatory amino acid antagonists which are certain thienopyridives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0398283-A1 | Excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-22 | — | — | EP | disclosed |