SCHEMBL940163

SCHEMBL940163

COc1cc2c(=O)oc3c(OC)c(OC)c(OC)c4c(=O)oc(c1OC)c2c34

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.69
CA1 P00915 3/20 0.69
CA7 P43166 3/20 0.69
CA9 Q16790 3/20 0.69
CA13 Q8N1Q1 3/20 0.69
RELA Q04206 1/20 0.69
ALDH1A1 P00352 5/20 0.56
KDM4E B2RXH2 4/20 0.56
HPGD P15428 3/20 0.56
MEN1 O00255 2/20 0.56
MAPT P10636 2/20 0.56
KMT2A Q03164 2/20 0.56
APEX1 P27695 1/20 0.56
RECQL P46063 1/20 0.56
BLM P54132 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
CA2 P00918 1/20 0.44
ABCB1 P08183 2/20 0.44
ABCG2 Q9UNQ0 2/20 0.44
CYP3A4 P08684 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3796697 0.91 CA12 (0.82) CA12CA1CA7CA9CA13
SCHEMBL941424 0.82 RELA (1.00) CA12CA1CA7CA9CA13
SCHEMBL30608638 0.82 RELA (1.00) CA12CA1CA7CA9CA13
SCHEMBL940860 0.79 CA12 (0.84) CA12CA1CA7CA9CA13
SCHEMBL11218491 0.77 CA12 (0.67) CA12CA1CA7CA9CA13
SCHEMBL10079564 0.74 ALDH1A1 (0.67) CA12CA1CA7CA9CA13
SCHEMBL38658338 0.74 CA12 (0.84) CA12CA1CA7CA9CA13
SCHEMBL941032 0.72 KDM4E (1.00) CA12CA1CA7CA9CA13
SCHEMBL29508368 0.72 KDM4E (1.00) CA12CA1CA7CA9CA13
SCHEMBL13815272 0.72 CA12 (0.58) CA12CA1CA7CA9CA13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1932514-B1 PHARMACEUTICAL PREPARATION FOR EXTERNAL APPLICATION TO SKIN COMPRISING PHOSPHORYLATED SUGAR EZAKI GLICO CO (JP) 2018-11-14 EP disclosed
US-20140023602-A1 EXTERNAL PREPARATION FOR SKIN CONTAINING A PHOSPHORYLATED SACCHARIDE EZAKI GLICO CO., LTD. (JP) 2014-01-23 US disclosed
US-20110014141-A1 TOPICAL AGENT FOR DERMATOLOGICAL USE DSM IP ASSETS B.V. (NL) 2011-01-20 US disclosed
EP-1932514-A1 PHARMACEUTICAL PREPARATION FOR EXTERNAL APPLICATION TO SKIN COMPRISING PHOSPHORYLATED SUGAR Ezaki Glico Co., Ltd. (JP) 2008-06-18 EP disclosed
EP-1859835-A2 Topical agent for dermatological use containing 4-hydroxyphenyl-alpha-D-glucopyranoside PENTAPHARM Ltd. (CH) 2007-11-28 EP disclosed
US-20030198610-A1 Topical agent for dermatological use DSM IP ASSETS B.V. (NL) 2003-10-23 US disclosed
EP-1289489-A2 TOPICAL AGENT FOR DERMATOLOGICAL USE CONTAINING 4-HYDROXYPHENYL-ALPHA-D-GLUCOPYRANOSIDE PENTAPHARM Ltd. (CH) 2003-03-12 EP disclosed
WO-2001091715-A2 TOPICAL AGENT FOR DERMATOLOGICAL USE CONTAINING 4-HYDROXYPHENYL-ALPHA-D-GLUCOPYRANOSIDE PENTAPHARM LTD. (CH) 2001-12-06 WO disclosed
US-6066312-A SKIN-LIGHTENING AND WHITENING EFFECTS LION CORPORATION (JP) 2000-05-23 US disclosed
EP-0294808-B1 AGENT FOR EXTERNAL APPLICATION AND USE THEREOF LION CORPORATION (JP) 1992-04-22 EP disclosed
EP-0294808-A1 Agent for external application and use thereof LION CORPORATION (JP) 1988-12-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110014141-A1 TOPICAL AGENT FOR DERMATOLOGICAL USE GALE, ALPP, UGGT1 CA12 1408/4885CA1 3805/4885CA7 1150/4885
US-20140023602-A1 EXTERNAL PREPARATION FOR SKIN CONTAINING A PHOSPHORYLATED SACCHARIDE SI, CUTA, CD44 CA12 173/4885CA1 356/4885CA7 252/4885
US-20030198610-A1 Topical agent for dermatological use GALE, UGGT1, UGDH CA12 1338/4885CA1 3907/4885CA7 1147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.