SCHEMBL9403340

SCHEMBL9403340

C=CCc1cc(-c2cc(CC=C)nc(CC=C)c2)ccn1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.36
PDE4C Q08493 1/20 0.36
PDE4D Q08499 1/20 0.36
GABRA1 P14867 1/20 0.35
GABRB2 P47870 1/20 0.35
SREBF2 Q12772 3/20 0.31
SREBF1 P36956 1/20 0.31
EGFR P00533 1/20 0.30
MAP4K4 O95819 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9301260 0.92 GABRA1 (0.39) PDE4APDE4CPDE4DGABRA1GABRB2
SCHEMBL8953846 0.85 MAPT (0.41) GABRA1GABRB2EGFRMAP4K4
SCHEMBL9301795 0.84 GABRA1 (0.35) PDE4APDE4CPDE4DGABRA1GABRB2
SCHEMBL11910285 0.79 MAPT (0.33) GABRA1GABRB2
SCHEMBL2410720 0.77 L3MBTL1 (0.40) PDE4APDE4CPDE4D
SCHEMBL2556929 0.76 XDH (0.45) GABRA1GABRB2
SCHEMBL797991 0.73 XDH (0.40) PDE4APDE4CPDE4DGABRA1GABRB2
SCHEMBL23139999 0.73 UHRF1 (0.45)
SCHEMBL629846 0.73 XDH (0.38) GABRA1GABRB2
SCHEMBL324742 0.73 ALDH1A1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5294376-A Rearview mirror GENTEX CORPORATION (US) 1994-03-15 US disclosed
US-5278693-A Tinted solution-phase electrochromic devices GENTEX CORPORATION (US) 1994-01-11 US disclosed