Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9412586 | 0.96 | RORC (0.46) | IDH1RORCITGB3ITGA2BHDAC1 | |
| SCHEMBL9412623 | 0.87 | MAPT (0.46) | IDH1SMN1; SMN2ITGB3ITGA2BHDAC6 | |
| SCHEMBL9412439 | 0.86 | ITGB3 (0.56) | IDH1RORCITGB3ITGA2BHDAC1 | |
| SCHEMBL9412511 | 0.84 | MAPT (0.45) | LMNASMN1; SMN2ITGB3ITGA2BTP53 | |
| SCHEMBL9412515 | 0.84 | JAK2 (0.47) | IDH1ITGB3ITGA2BROCK2 | |
| SCHEMBL9412697 | 0.83 | SMN1; SMN2 (0.47) | HPGDSMN1; SMN2ITGB3ITGA2BHDAC1 | |
| SCHEMBL9412727 | 0.83 | POLB (0.46) | ALDH1A1LMNASMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL9412665 | 0.82 | MAPT (0.45) | IDH1SMN1; SMN2ITGB3ITGA2BHDAC6 | |
| SCHEMBL9412536 | 0.82 | ITGB3 (0.46) | IDH1SMN1; SMN2ITGB3ITGA2BROCK2 | |
| SCHEMBL9412452 | 0.82 | MAPT (0.44) | IDH1SMN1; SMN2ITGB3ITGA2BHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611660-A2 | Condensed 5-membered heterocycles, process for their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1994-08-24 | — | — | EP | disclosed |