Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.68 |
| ▸ | MAOA | P21397 | 3/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.68 |
| ▸ | HTR3A | P46098 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | SCN1A | P35498 | 4/20 | 0.65 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.65 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295410 | 0.88 | HRH3 (0.68) | HRH3TSHRMAOACYP2D6HTR3A | |
| SCHEMBL6677 | 0.87 | HRH3 (0.67) | HRH3TSHRMAOACYP2D6HTR3A | |
| SCHEMBL9576578 | 0.87 | HRH3 (0.71) | HRH3TSHRMAOACYP2D6HTR3A | |
| SCHEMBL9865362 | 0.85 | SMN1; SMN2 (0.65) | HRH3TSHRMAOACYP2D6HTR3A | |
| Hydrochloric Acid SCHEMBL24097 | 0.85 | BLM (0.68) | HRH3TSHRMAOACYP2D6HTR3A | |
| Water SCHEMBL8171709 | 0.85 | HRH3 (0.65) | HRH3TSHRMAOACYP2D6HTR3A | |
| Iodide SCHEMBL1022754 | 0.85 | HRH3 (0.65) | HRH3TSHRMAOACYP2D6HTR3A | |
| Hydrochloric Acid SCHEMBL9543350 | 0.85 | BLM (0.72) | HRH3TSHRMAOACYP2D6HTR3A | |
| SCHEMBL3364980 | 0.85 | HPGD (0.68) | HRH3TSHRMAOACYP2D6HTR3A | |
| SCHEMBL23663776 | 0.84 | PHLPP2 (0.67) | HRH3TSHRMAOACYP2D6HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220016046-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2022-01-20 | — | — | US | claimed |
| US-20210290561-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2021-09-23 | — | — | US | claimed |
| US-20210186906-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-06-24 | — | — | US | claimed |
| US-9603817-B2 | Methods, compositions, and kits for treating pain and pruritis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-03-28 | — | — | US | claimed |
| US-20150087714-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-03-26 | — | — | US | claimed |
| EP-2101819-B1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | HARVARD COLLEGE (US) | 2013-01-09 | — | — | EP | claimed |
| US-20120172429-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI- INFLAMMATORY AGENTS | THE GENERAL HOSPITAL CORPORATION | 2012-07-05 | — | — | US | claimed |
| CN-102112121-A | Methods, compositions, and kits for treating pain and pruritis | HARVARD COLLEGE | 2011-06-29 | — | — | CN | claimed |
| JP-2011513484-A | — | — | 2011-04-28 | — | — | JP | claimed |
| US-20110086818-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2011-04-14 | — | — | US | claimed |
| EP-2271329-A2 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | President and Fellows of Harvard College (US) | 2011-01-12 | — | — | EP | claimed |
| US-20100099772-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | claimed |
| CN-101610789-A | Methods, compositions and kits for treating pain and itch | HARVARD COLLEGE (US) | 2009-12-23 | — | — | CN | claimed |
| EP-2101819-A2 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2009114139-A2 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-09-17 | — | — | WO | claimed |
| WO-2008063603-A2 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-05-29 | — | — | WO | claimed |
| EP-3485881-B1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | HARVARD COLLEGE (US) | 2024-03-13 | — | — | EP | disclosed |
| US-20230346942-A1 | MACROMOLECULAR PRODRUGS FOR LIGHT-EMITTING DIODES AND USES THEREOF | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2023-11-02 | — | — | US | disclosed |
| US-5252563-A | 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine compounds for treatment of neurotoxic injury | G. D. SEARLE & COMPANY (US) | 1993-10-12 | — | — | US | disclosed |
| US-5216003-A | Antihypoxic, antiischemic agents | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172429-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI- INFLAMMATORY AGENTS | TRPV1, CACNA1B, ORAI1 | HRH3 251/4885TSHR 4201/4885MAOA 3680/4885 |
| US-20110086818-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS | TRPV1, OPRL1, ITCH | HRH3 151/4885TSHR 3892/4885MAOA 2901/4885 |
| US-20100099772-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | TRPV1, TRPV2, TRPV3 | HRH3 122/4885TSHR 744/4885MAOA 1318/4885 |
| US-20150087714-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | TRPV1, TRPV2, TRPA1 | HRH3 135/4885TSHR 844/4885MAOA 1400/4885 |
| US-20210290561-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | TRPV1, CACNA1B, ORAI1 | HRH3 251/4885TSHR 4201/4885MAOA 3680/4885 |
| US-20220016046-A1 | PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS | CACNA1B, TRPV1, ORAI1 | HRH3 271/4885TSHR 4135/4885MAOA 3776/4885 |
| US-20210186906-A1 | METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS | TRPV1, TRPV2, TRPV3 | HRH3 122/4885TSHR 744/4885MAOA 1318/4885 |
| US-20230346942-A1 | MACROMOLECULAR PRODRUGS FOR LIGHT-EMITTING DIODES AND USES THEREOF | CRY1, MAPT, PYGL | HRH3 2923/4885TSHR 4119/4885MAOA 885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.