Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | SHBG | P04278 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417792 | 0.88 | RXRA (0.54) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL9417853 | 0.87 | SHBG (0.47) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL29054771 | 0.85 | GAA (0.53) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL30544801 | 0.85 | GAA (0.53) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL9417833 | 0.83 | ALDH1A1 (0.64) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL295850 | 0.83 | KMT2A (0.68) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL10031634 | 0.83 | MAPT (0.73) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL27993896 | 0.83 | MAPT (0.64) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL7042702 | 0.82 | MAPT (0.55) | LMNAMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL170272 | 0.81 | LMNA (0.66) | LMNAMAPTHPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294613-A | Benzene derivatives of p-substituted ether and acid or ester | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0276065-A1 | Anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |